Trial to Improve Outcomes in Patients With Resected Pancreatic Cancer (Azacitidine, Abraxane, Gemcitabine)

This trial is for patients with resected pancreatic adenocarcinoma who have concluded
adjuvant therapy or were deemed unable to receive adjuvant therapy with an elevated CA 19-9
or node positive or margin positive disease. CA 19-9 elevation is defined as two levels > the
institutional upper limit of normal (ULN) taken at least 2 weeks apart. These levels should
be measured after adjuvant therapy has concluded or upon the decision that adjuvant therapy
will not be offered. Patients will be randomized to one of two arms. Subjects enrolled due to
node + disease or R1 resection must be able to undergo randomization within 3 months of
finishing adjuvant therapy or the decision that they are unable to take adjuvant therapy.
Patients enrolling due to CA 19-9 elevations can enroll any time after adjuvant therapy has
completed. Group A, the treatment arm, will be started on CC-486 (oral azacitidine). Group B,
the control arm, will receive no additional therapy. Both Arms will evaluate CA 19-9 and have
CT scans every 3 months. When patients have visible disease recurrence on imaging, CC-486
will be stopped and both groups will start first-line chemotherapy (possibly abraxane or
gemcitabine).

GOALS:

To improve progression free survival in high risk patients with resected pancreatic
adenocarcinoma who have node positive disease, margin positive disease, and/or elevation in
CA 19-9 treated with CC-486 (oral azacitidine)as compared to observation after completion of
adjuvant therapy.

To improve response rates to first-line chemotherapy (partial and complete response) after
recurrence in patients treated with CC-486 after completing adjuvant therapy.

To improve overall survival in patients with resected pancreatic adenocarcinoma treated with
CC-486.

To evaluate resected pancreatic cancer tissue and biopsies at time of recurrence for
epigenetic and genetic alterations to determine the pharmacodynamic effects of CC-486.

To evaluate resected pancreatic cancer tissue to identify predictive signatures of possible
recurrence and the benefit of hypomethylating therapy.

Inclusion Criteria:

- Understand and voluntarily sign an informed consent form.

- Age greater than or 18 years at the time of signing the informed consent form.

- Able to adhere to the study visit schedule and other protocol requirements.

- Subjects must have a histologically confirmed pancreatic adenocarcinoma that has had
an R0 (negative margins) or R1 (microscopically positive margins) resection.

- Subjects must have finished adjuvant therapy, which can include chemotherapy and/or
chemoradiation therapy or have been determined to be unable to take adjuvant therapy.
Although patients will be expected to complete chemoradiation or chemotherapy per
physician recommendations, patients who are unable to complete chemotherapy ±
radiation therapy secondary to dose limiting toxicities will be eligible provided they
meet study criteria.

- Subjects enrolled due to node + disease or R1 resection must be able to undergo
randomization within 3 months of finishing adjuvant therapy or the decision that they
are unable to take adjuvant therapy. Patients enrolling due to CA 19-9 elevations can
enroll any time after adjuvant therapy has completed.

- All previous cancer therapy including radiation, chemotherapy, and surgery, must have
been discontinued at least 4 weeks prior to treatment in this study

- Subjects must either have a CA 19-9 value > the institutional ULN on two separate
checks at least 2 weeks apart OR have had an R1 resection margin OR N1 nodal disease
regardless of CA 19-9 level

- Subjects must be free of visible disease on imaging (CT, PETCT or MRI) evaluating
chest, abdomen, and pelvis within 28 days of enrollment on the study.

- Life expectancy of greater than 12 weeks

- ECOG performance status of less than or equal to 1 at study entry

- Subjects must have normal organ and marrow function

- Free of prior malignancies for greater than or equal to 5 years with exception of
currently treated basal cell, squamous cell carcinoma of the skin, or carcinoma in
situ of the cervix or breast.

- Women of childbearing potential should be advised to avoid becoming pregnant and men
should be advised to not father a child while receiving treatment with CC-486 or
nab-paclitaxel. All men and women of childbearing potential must use effective methods
of birth control throughout the study and for three months after completing treatment.

- Women of childbearing potential must have a negative serum or urine β-hCG pregnancy
test at screening.

- Subjects must have < Grade 2 pre-existing peripheral neuropathy (per CTCAE)

Exclusion Criteria:

- Any serious medical condition, laboratory abnormality, or psychiatric illness that
would prevent the subject from signing the informed consent form.

- Pregnant or breastfeeding women.

- Use of any other chemotherapy, radiotherapy, or experimental drug or therapy within 4
weeks (6 weeks for nitrosoureas or mitomycin C) prior to enrollment on study or those
who have not recovered from adverse events ≥ grade 1 due to agents administered more
than 4 weeks earlier except for stable grade 2 neuropathy.

- Subjects may not receive any other concomitant investigational agents.

- Known or suspected hypersensitivity to 5-azacitidine or mannitol

- Known positive for HIV or infectious hepatitis, type B or C. HIV patients are at
increased risk of lethal infections when treated with marrow-suppressive therapy.

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements.

- Any known gastrointestinal disorders which would preclude oral administration of
5-azacitidine.