Effects Contrast on Platelet Activity, Thrombosis and Fibrinolysis in Patients Undergoing Coronary Angiography
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | February 2013 |
| End Date: | November 2014 |
The Assesment of Thrombotic Markers Utilizing Ionic Versus Non-Ionic Contrast During Coronary Angiography and Intervention (AToMIC) Trial
The aim of this study is to determine how two different types of iodinated contrast media
(CM) agents, low-osmolar ionic ioxaglate and iso-osmolar non-ionic iodixanol, affect
specific markers of thrombogenesis and platelet function in patients undergoing coronary
angiography, and if the use of bivalirudin, a direct thrombin inhibitor used during
percutaneous coronary intervention (PCI), affects any contrast-related changes in
thrombogenesis and platelet function.
(CM) agents, low-osmolar ionic ioxaglate and iso-osmolar non-ionic iodixanol, affect
specific markers of thrombogenesis and platelet function in patients undergoing coronary
angiography, and if the use of bivalirudin, a direct thrombin inhibitor used during
percutaneous coronary intervention (PCI), affects any contrast-related changes in
thrombogenesis and platelet function.
Inclusion Criteria:
- Patients must be more than 18 years of age
- referred for coronary angiography and on dual anti-platelet therapy (aspirin and
clopidogrel).
Exclusion Criteria:
- on warfarin
- on low molecular weight heparin within 12 hours of coronary angiography or
unfractionated heparin with activated clotting time >150 at time of procedure -on
cilostazol
- on persantine
- on non- steroidal anti-inflammatory medications (ibuprofen/motrin/advil,
naproxen/aleve, indomethacin, sulindac, etodolac, diclofenac, celecoxib) within 72
hours of procedure
- on prasugrel (not an exclusion criteria for ST-segment elevation myocardial
infarction registry
- undergoing coronary angiography via radial access
- undergoing planned diagnostic coronary angiography only
- unable to tolerate dual anti-platelet therapy
- with known allergy to CM
- received CM within 24 hours of coronary angiography
- on dialysis
- do not consent or are unable to give consent
- are participating in another competing study.
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