Imaging Dopamine Function and Its Impact on Outcome After Traumatic Brain Injury (TBI)

Inclusion Criteria:

- Non-penetrating TBI

- Age between 18-50 years old

- Admitted to a North Texas TBI Model Systems-affiliated rehabilitation facility within
16 weeks of injury

- Rated at Rancho VI Los Amigos Levels of Cognitive Functioning Scale of less than or
equal to Stage V at the time of enrollment

- Disability Rating Scale total score >/= 7

Exclusion Criteria:

- Central Nervous System disorder resulting in functional disability predating TBI

- Documented diagnosis of disease processes impacted by the dopamine system (e.g.,
Parkinson's Disease, clinician diagnosed Attention Deficit Hyperactivity Disorder,
substance abuse/dependence (excluding marijuana, alcohol, tobacco), or schizophrenia)

- Pre-injury use of dopaminergic pharmaceuticals (i.e., methylphenidate, amantadine, or
dopamine receptor blockers such as olanzapine or quetiapine)

- Documented contraindication to use of methylphenidate including allergy

- Uncontrolled epilepsy

- Pregnant

- Medical condition not compatible with use of Methylphenidate

- Recent diagnosis or therapeutic study using radiopharmaceuticals

- Contraindications to the use of Ioflupane

- Allergic to Iodine