Gadofosveset Trisodium for Heart Imaging Studies
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 9/12/2018 |
| Start Date: | March 8, 2013 |
| End Date: | December 13, 2016 |
A Pilot Dosing Study for Gadofosveset Trisodium (Ablavar) for Coronary Magnetic Resonance Angiography (MRA)
Background:
- Magnetic resonance imaging (MRI) is type of imaging study that uses magnetic fields and
radio waves to take pictures of the body. To help the images show up more clearly, a contrast
agent is injected into a vein. Researchers are interested in finding contrast agents that can
help show problems with the blood vessels around the heart. They want to test an agent called
Gadofosveset Trisodium to see how it works in MRI scans.
Objectives:
- To test the effectiveness of Gadofosveset Trisodium as a contrast agent in heart MRI scans.
Eligibility:
- Healthy volunteers between 18 and 45 years of age.
Design:
- Participants will be screened with a physical exam and medical history. They will
provide blood samples before the scanning sessions.
- Participants will have an MRI scan after the screening visit. They will have a dose of
the contrast scan before the study.
- Participants will return for one additional MRI scan within 1 to 2 months of each scan.
Different doses of the contrast agent will be used for each scan.
- An additional blood sample will be collected within 1 week of the second MRI scan.
- Magnetic resonance imaging (MRI) is type of imaging study that uses magnetic fields and
radio waves to take pictures of the body. To help the images show up more clearly, a contrast
agent is injected into a vein. Researchers are interested in finding contrast agents that can
help show problems with the blood vessels around the heart. They want to test an agent called
Gadofosveset Trisodium to see how it works in MRI scans.
Objectives:
- To test the effectiveness of Gadofosveset Trisodium as a contrast agent in heart MRI scans.
Eligibility:
- Healthy volunteers between 18 and 45 years of age.
Design:
- Participants will be screened with a physical exam and medical history. They will
provide blood samples before the scanning sessions.
- Participants will have an MRI scan after the screening visit. They will have a dose of
the contrast scan before the study.
- Participants will return for one additional MRI scan within 1 to 2 months of each scan.
Different doses of the contrast agent will be used for each scan.
- An additional blood sample will be collected within 1 week of the second MRI scan.
The purpose of this study is to determine if the diagnostic quality of contrast-enhanced
coronary magnetic resonance angiography (MRA) is improved by using a higher versus a lower
dose of a gadolinium-based contrast agent. We will compare two doses of an intravascular
contrast agent (Gadofosveset, 0.03 and 0.06 mmol/kg) in this pilot dosing study. Healthy
participants will be recruited who do not have a clinical indication for MR angiography but
do have safety clearance for IV gadolinium contrast and MR scanning.
Subjects will be evaluated in order to determine if the signal to noise ratio (SNR) and
contrast to noise ratio (CNR) of the coronary arteries is increased for the higher dose
contrast agent. Parameters will be compared with paired t-testing for significance.
coronary magnetic resonance angiography (MRA) is improved by using a higher versus a lower
dose of a gadolinium-based contrast agent. We will compare two doses of an intravascular
contrast agent (Gadofosveset, 0.03 and 0.06 mmol/kg) in this pilot dosing study. Healthy
participants will be recruited who do not have a clinical indication for MR angiography but
do have safety clearance for IV gadolinium contrast and MR scanning.
Subjects will be evaluated in order to determine if the signal to noise ratio (SNR) and
contrast to noise ratio (CNR) of the coronary arteries is increased for the higher dose
contrast agent. Parameters will be compared with paired t-testing for significance.
- INCLUSION CRITERIA:
A. Able to understand and sign informed consent.
B. Able to complete an MRI scan.
C. Age 18-45 years old.
D. eGFR greater than or equal to 60mL/min/1.73m(2) within 1 week prior to gadolinium
injection.
E. NIH employees may be involved and NIH requirements will be followed as laid out in NIH
Policy Manual 2300-630-3 - Leave Policy for NIH Employees Participating in NIH Medical
Research Studies.
F. Willing to travel to the NIH for scheduled follow-up visits and scans as well as
potential repeat scans in the event of sub-optimal scanning.
EXCLUSION CRITERIA:
Individuals will be excluded from the study if they have:
A. Contra-indications to undergoing a MRA
Please review Radiology MRI section MRI safety questionnaire.
B. MRI with contrast within the last 6 months (self-reported) outside of our protocol.
C. Contra indications to receiving gadolinium-based contrast agent (specified here and on
MRI safety questionnaire):
1. Allergy to gadolinium-based contrast
2. Labs:
i. Kidney and liver function above the upper limits of normal
ii. eGFR < 60ml/min/1.73m(2)
iii. Pregnancy test: positive
c. Acute renal failure, renal transplantation, curent dialysis treatment or hepatorenal
syndrome
d. History of liver transplantation or severe liver disease
e. Severe Asthma
f. Hemoglobinopathies
g. History of multiple myeloma
h. History of significant allergic reaction to gadolinium-based contrast agents
i. Evaluated to be at increased risk for Nephrogenic Systemic Fibrosis (NSF).
D. Current written (or self-reported) record of:
1. atrial fibrillation
2. cardiac surgery
3. cancer treatment
4. other comorbid conditions that otherwise indicates the participant has renal function
that may deteriorate between study procedures due to the participant s underlying
medical condition or that would not allow the study subject to complete the protocol.
E. Current written (or self-reported) record of active:
1. Clinically diagnosed angina, heart failure, and/or clinically significant electrical
conduction abnormality in the heart.
2. Pregnancy or lactation
3. Mental, neurologic or social condition preventing understanding of the rationale,
procedures, risks and potential benefits associated with the trial
4. Paralyzed hemidiaphragm
5. Over 400 lbs and/or a body circumference that prevents adequate MRI gantry insertion.
6. Unable to lay flat in the scanner
7. Claustrophobia otherwise requiring anesthesia or sedation to undergo MRI.
8. Participant is not able to undergo intravenous line placement and/or refuse gadolinium
contrast.
F. Any other conditions that precludes safety for MRI per the researcher s evaluation.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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