Open Label Study of Long Term Evaluation Against LDL-C Trial-2



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 85
Updated:11/4/2018
Start Date:April 23, 2013
End Date:May 18, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Multicenter, Controlled, Open-label Extension (OLE) Study to Assess the Long-term Safety and Efficacy of AMG 145-2

This study will contribute to the evaluation of long-term safety, tolerability and efficacy
of evolocumab (AMG 145) in subjects with hyperlipidemia and subjects with mixed dyslipidemia.


Inclusion Criteria:

- Complete a qualifying evolocumab (AMG 145) parent study

Exclusion Criteria:

- Experienced a treatment-related serious adverse event that led to IP discontinuation
in the parent study

- Have an unstable medical condition, in the judgment of the investigator

- Known sensitivity to any of the products to be administered during dosing

- Currently enrolled in another investigational device or drug study (excluding
evolocumab (AMG 145) parent study), or less than 30 days since ending another
investigational device or drug study(s),or receiving other investigational agent(s)
We found this trial at
108
sites
Clinical Trial Facility in San Antonio Texas
San Antonio, Texas 78224
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Clinical Trial Facility in Akron Ohio
Akron, Ohio
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Akron, OH
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Clinical Trial Facility in Anderson South Carolina
Anderson, South Carolina
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Anderson, SC
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Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
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Atlanta, GA
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Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
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Atlanta, GA
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Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
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Atlanta, GA
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Clinical Trial Facility in Auburn Maine
Auburn, Maine 04210
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Auburn, ME
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Clinical Trial Facility in Austin Texas
Austin, Texas 78744
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Austin, TX
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Clinical Trial Facility in Ayer Massachusetts
Ayer, Massachusetts
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Ayer, MA
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Clinical Trial Facility in Bangor Maine
Bangor, Maine 04402
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Bangor, ME
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Clinical Trial Facility in Bethesda Maryland
Bethesda, Maryland
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Bethesda, MD
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Clinical Trial Facility in Beverly Hills California
Beverly Hills, California 90211
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Beverly Hills, CA
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Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
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Birmingham, AL
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Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
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Birmingham, AL
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Clinical Trial Facility in Cadiz Ohio
Cadiz, Ohio 43907
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Cadiz, OH
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Clinical Trial Facility in Camperdown New South Wales
Camperdown, New South Wales 2050
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Camperdown,
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Clinical Trial Facility in Canton Ohio
Canton, Ohio 44718
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Canton, OH
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Clinical Trial Facility in Carmichael California
Carmichael, California 95608
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Carmichael, CA
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Clinical Trial Facility in Chandler Arizona
Chandler, Arizona 85224
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Chandler, AZ
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Clinical Trial Facility in Charleston South Carolina
Charleston, South Carolina 29412
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Charleston, SC
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Clinical Trial Facility in Chicago Illinois
Chicago, Illinois
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Chicago, IL
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Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
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Cincinnati, OH
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Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
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Cincinnati, OH
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Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
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Cincinnati, OH
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Clinical Trial Facility in Cleveland Ohio
Cleveland, Ohio
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Cleveland, OH
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Clinical Trial Facility in Columbia Maryland
Columbia, Maryland 21044
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Columbia, MD
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Clinical Trial Facility in Dallas Texas
Dallas, Texas 75390
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Dallas, TX
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Clinical Trial Facility in Dallas Texas
Dallas, Texas 75390
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Dallas, TX
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Clinical Trial Facility in Dayton Ohio
Dayton, Ohio 45409
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Dayton, OH
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Clinical Trial Facility in Daytona Beach Florida
Daytona Beach, Florida 32117
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Daytona Beach, FL
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Clinical Trial Facility in DeLand Florida
DeLand, Florida 32720
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DeLand, FL
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Clinical Trial Facility in Duncansville Pennsylvania
Duncansville, Pennsylvania 16635
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Duncansville, PA
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Clinical Trial Facility in Edina Minnesota
Edina, Minnesota 55414
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Edina, MN
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Clinical Trial Facility in Encinitas California
Encinitas, California 92024
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Encinitas, CA
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Clinical Trial Facility in Endwell New York
Endwell, New York
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Endwell, NY
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Clinical Trial Facility in Fargo North Dakota
Fargo, North Dakota 58122
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Fargo, ND
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Clinical Trial Facility in Gainesville Georgia
Gainesville, Georgia 30505
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Gainesville, GA
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Clinical Trial Facility in Henderson Nevada
Henderson, Nevada
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Henderson, NV
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Clinical Trial Facility in Hillsboro Oregon
Hillsboro, Oregon 97123
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Hillsboro, OR
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Clinical Trial Facility in Houston Texas
Houston, Texas
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Houston, TX
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Clinical Trial Facility in Houston Texas
Houston, Texas
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Houston, TX
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Clinical Trial Facility in Huntington Beach California
Huntington Beach, California 92646
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Huntington Beach, CA
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Clinical Trial Facility in Indianapolis Indiana
Indianapolis, Indiana 46202
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Indianapolis, IN
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Clinical Trial Facility in Iowa City Iowa
Iowa City, Iowa 52242
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Iowa City, IA
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Clinical Trial Facility in Jackson Tennessee
Jackson, Tennessee 38305
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Jackson, TN
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Clinical Trial Facility in Jacksonville Florida
Jacksonville, Florida 32209
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Jacksonville, FL
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Clinical Trial Facility in Kansas City Kansas
Kansas City, Kansas
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Kansas City, KS
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Clinical Trial Facility in Lansdale Pennsylvania
Lansdale, Pennsylvania
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Lansdale, PA
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Clinical Trial Facility in Las Vegas Nevada
Las Vegas, Nevada 89135
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Las Vegas, NV
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Clinical Trial Facility in Lexington Kentucky
Lexington, Kentucky
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Lexington, KY
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Clinical Trial Facility in Little Rock Arkansas
Little Rock, Arkansas
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Little Rock, AR
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Clinical Trial Facility in Littleton Colorado
Littleton, Colorado 80120
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Littleton, CO
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Clinical Trial Facility in Los Angeles California
Los Angeles, California
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Los Angeles, CA
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Clinical Trial Facility in Louisville Kentucky
Louisville, Kentucky 40202
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Louisville, KY
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Clinical Trial Facility in Manlius New York
Manlius, New York 13104
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Manlius, NY
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Clinical Trial Facility in Mansfield Ohio
Mansfield, Ohio
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Mansfield, OH
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Clinical Trial Facility in Marion Ohio
Marion, Ohio 43302
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Marion, OH
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Clinical Trial Facility in Melbourne Florida
Melbourne, Florida
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Melbourne, FL
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Clinical Trial Facility in Miami Florida
Miami, Florida 33136
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Miami, FL
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Clinical Trial Facility in Miami Florida
Miami, Florida 33136
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Miami, FL
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Clinical Trial Facility in Mission Viejo California
Mission Viejo, California 92691
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Mission Viejo, CA
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Clinical Trial Facility in Monroe Louisiana
Monroe, Louisiana
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Monroe, LA
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Clinical Trial Facility in Mount Pleasant South Carolina
Mount Pleasant, South Carolina 29464
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Mount Pleasant, SC
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Clinical Trial Facility in Munster Indiana
Munster, Indiana 46321
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Munster, IN
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Clinical Trial Facility in Nashville Tennessee
Nashville, Tennessee 37232
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Nashville, TN
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Clinical Trial Facility in New Windsor New York
New Windsor, New York 12553
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New Windsor, NY
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Clinical Trial Facility in New York New York
New York, New York 10032
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New York, NY
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Clinical Trial Facility in Newport Beach California
Newport Beach, California 92660
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Newport Beach, CA
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Clinical Trial Facility in Norfolk Virginia
Norfolk, Virginia 23507
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Norfolk, VA
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Clinical Trial Facility in Norman Oklahoma
Norman, Oklahoma 73069
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Norman, OK
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Clinical Trial Facility in Oklahoma City Oklahoma
Oklahoma City, Oklahoma
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Oklahoma City, OK
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Clinical Trial Facility in Olive Branch Mississippi
Olive Branch, Mississippi 38654
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Olive Branch, MS
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Clinical Trial Facility in Phoenix Arizona
Phoenix, Arizona
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Phoenix, AZ
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Clinical Trial Facility in Pittsburgh Pennsylvania
Pittsburgh, Pennsylvania
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Pittsburgh, PA
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Clinical Trial Facility in Ponte Vedra Florida
Ponte Vedra, Florida 32081
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Ponte Vedra, FL
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Clinical Trial Facility in Port Charlotte Florida
Port Charlotte, Florida 33952
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Port Charlotte, FL
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Clinical Trial Facility in Portland Maine
Portland, Maine 04102
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Portland, ME
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Clinical Trial Facility in Quincy Massachusetts
Quincy, Massachusetts 62301
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Quincy, MA
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Clinical Trial Facility in Raleigh North Carolina
Raleigh, North Carolina 27607
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Raleigh, NC
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Clinical Trial Facility in Raleigh North Carolina
Raleigh, North Carolina 27607
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Raleigh, NC
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Clinical Trial Facility in Rapid City South Dakota
Rapid City, South Dakota 57701
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Rapid City, SD
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Clinical Trial Facility in Rapid City South Dakota
Rapid City, South Dakota 57701
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Rapid City, SD
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Clinical Trial Facility in Renton Washington
Renton, Washington 98057
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Renton, WA
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Clinical Trial Facility in Richmond Virginia
Richmond, Virginia 23227
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Richmond, VA
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Clinical Trial Facility in Rochester New York
Rochester, New York
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Rochester, NY
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Clinical Trial Facility in Saint Louis Missouri
Saint Louis, Missouri 63110
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Saint Louis, MO
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Clinical Trial Facility in San Diego California
San Diego, California
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San Diego, CA
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Clinical Trial Facility in Sandusky Ohio
Sandusky, Ohio
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Sandusky, OH
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Clinical Trial Facility in Sanford Florida
Sanford, Florida 32771
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Sanford, FL
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Clinical Trial Facility in Santa Ana California
Santa Ana, California 92701
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Santa Ana, CA
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Clinical Trial Facility in Santa Rosa California
Santa Rosa, California 95405
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Santa Rosa, CA
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Clinical Trial Facility in Savannah Georgia
Savannah, Georgia 31406
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Savannah, GA
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Clinical Trial Facility in Seattle Washington
Seattle, Washington 98105
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Seattle, WA
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Clinical Trial Facility in Spring Valley California
Spring Valley, California 91978
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Spring Valley, CA
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Clinical Trial Facility in Sterling Illinois
Sterling, Illinois 61081
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Sterling, IL
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Clinical Trial Facility in Suffolk Virginia
Suffolk, Virginia 23434
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Suffolk, VA
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Clinical Trial Facility in Tacoma Washington
Tacoma, Washington
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Tacoma, WA
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Clinical Trial Facility in Thousand Oaks California
Thousand Oaks, California 91360
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Thousand Oaks, CA
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Clinical Trial Facility in Torrance California
Torrance, California
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Torrance, CA
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Clinical Trial Facility in Towson Maryland
Towson, Maryland 21204
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Towson, MD
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Clinical Trial Facility in Tucson Arizona
Tucson, Arizona 85724
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Tucson, AZ
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