Green Tea Confections For Managing Postprandial Hyperglycemia-Induced Vascular Endothelial Dysfunction
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Diabetes |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 30 |
| Updated: | 4/21/2016 |
| Start Date: | May 2013 |
| End Date: | April 2016 |
The objective of this study is to formulate and validate a green tea confection (i.e.
"gummy" candy) as a strategy to attenuate postprandial hyperglycemia-induced impairments in
vascular function. The central hypothesis is that a green tea confection will protect
against vascular endothelial dysfunction by suppressing postprandial hyperglycemia. The
central hypothesis of this application will be assessed by developing a green tea-containing
confection, examining its physiochemical properties and its inhibition of starch digestion,
and then validating its vasoprotective activities in healthy humans by assessing its blood
glucose-regulating activities.
"gummy" candy) as a strategy to attenuate postprandial hyperglycemia-induced impairments in
vascular function. The central hypothesis is that a green tea confection will protect
against vascular endothelial dysfunction by suppressing postprandial hyperglycemia. The
central hypothesis of this application will be assessed by developing a green tea-containing
confection, examining its physiochemical properties and its inhibition of starch digestion,
and then validating its vasoprotective activities in healthy humans by assessing its blood
glucose-regulating activities.
The study involves validating a green tea confection (i.e. "gummy" candy) as a dietary
strategy to attenuate postprandial hyperglycemia-induced impairments in vascular function.
The central hypothesis is that a green tea confection will protect against vascular
endothelial dysfunction by suppressing postprandial hyperglycemia. The central hypothesis of
this application will be assessed by providing research participants 75 grams of
carbohydrate in the form of a confection that contains no green tea concentrate or green tea
concentrate at a level equivalent to approximately 3 cups of freshly brewed tea. Blood
glucose and brachial artery flow-mediated dilation will be assessed at regular intervals
during the 3 hour postprandial period to define the extent to which green tea attenuates
postprandial increases in blood glucose and decreases in vascular function that otherwise
occur in a hyperglycemia-dependent manner.
strategy to attenuate postprandial hyperglycemia-induced impairments in vascular function.
The central hypothesis is that a green tea confection will protect against vascular
endothelial dysfunction by suppressing postprandial hyperglycemia. The central hypothesis of
this application will be assessed by providing research participants 75 grams of
carbohydrate in the form of a confection that contains no green tea concentrate or green tea
concentrate at a level equivalent to approximately 3 cups of freshly brewed tea. Blood
glucose and brachial artery flow-mediated dilation will be assessed at regular intervals
during the 3 hour postprandial period to define the extent to which green tea attenuates
postprandial increases in blood glucose and decreases in vascular function that otherwise
occur in a hyperglycemia-dependent manner.
Inclusion Criteria:
- Plasma glucose <100 mg/dL
- Plasma total cholesterol <200 mg/dL
- Plasma triglycerides <140 mg/dL
- Blood pressure <140/90
- non-dietary supplement user for >2 months
- no use of medications known to affect carbohydrate metabolism,
- nonsmoker / never smoker
- no history of cardiovascular disease or gastrointestinal disorders
Exclusion Criteria:
- allergies or aversions to green tea and/or corn starch,
- excessive alcohol consumption (>3 drinks/d),
- >5 h/wk of aerobic activity
We found this trial at
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Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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