Using Continuous Positive Airway Pressure to Reduce the Incidence of Acute Kidney Injury in Hospitalized Patients With Chronic Kidney Disease



Status:Completed
Conditions:Insomnia Sleep Studies, Renal Impairment / Chronic Kidney Disease, Hospital, Pulmonary
Therapuetic Areas:Nephrology / Urology, Psychiatry / Psychology, Pulmonary / Respiratory Diseases, Other
Healthy:No
Age Range:19 - Any
Updated:4/2/2016
Start Date:June 2013
End Date:July 2014
Contact:Stephanie P Taylor, MD
Email:spezzo@health.usf.edu
Phone:8138443401

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Using CPAP to Prevent Acute Kidney Injury in Hospitalized Patients With Chronic Kidney Disease

Obstructive sleep apnea (OSA) is a common and undertreated condition in patients with
chronic kidney disease (CKD). Both physiologic and empiric data suggest that renal hypoxia
due to OSA is associated with worsening kidney function. Hospitalized patients are often
exposed to multiple nephrotoxins such as antibiotics, contrast agents, and diuretics, which
place them at risk for acute worsening of kidney function. This study aims to determine
whether immediate diagnosis and treatment of OSA in CKD patients will decrease the incidence
of acute kidney injury during hospitalization. The investigators will evaluate the extent to
which this effect can be attributed to a decrease in nocturnal hypoxia and improved blood
pressure control. Secondary endpoints include hospital length of stay, and a composite
outcome comprised of hemodialysis initiation, major cardiovascular events, and mortality.


Inclusion Criteria:

1. CKD defined by National Kidney Foundation Staging system: eGFR < 60

2. Overnight sleep study consistent with OSA

Exclusion Criteria:

1. Currently treated with positive airway pressure for sleep-disordered breathing

2. Hemodynamically unstable, defined as SBP < 90, or use of vasopressors

3. Intubated or mechanically ventilated

4. Respiratory insufficiency, defined as P/F ratio < 250, or requiring mechanical
ventilation

5. End stage renal disease on renal replacement therapy

6. Contraindication to CPAP, including active emesis, recent intracranial surgery,
altered level of consciousness
We found this trial at
1
site
1 Tampa General Cir
Tampa, Florida 33606
(813) 844-7000
Tampa General Hospital In a diverse city known for its rich culture and beautiful beaches,...
?
mi
from
Tampa, FL
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