LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease

Inclusion Criteria:

Parkinson's disease inclusion criteria:

Inclusion criteria will be based on UK Brain Bank criteria for the clinical diagnosis of
PD. These require 1) the presence of bradykinesia and either rest tremor or rigidity; 2)
asymmetric onset; 3) progressive motor symptoms 4) age at onset 21-99 years.

Control inclusion criteria: ages of between 21-99 years, a lack of PD in first-degree blood
relatives, and a lack of positive responses on more than 3 items on the PD Screening
Questionnaire.

Exclusion Criteria:

For all subjects:

include atypical features indicative of a Parkinson-Plus disorder (Progressive Supranuclear
Palsy (PSP), Multiple System Atrophy (MSA), Corticobasal Degeneration (CBD)) including
cerebellar signs, supranuclear gaze palsy, apraxia and other cortical signs, or prominent
autonomic failure, neuroleptic treatment at time of onset of parkinsonism, active treatment
with a neuroleptic at time of study entry, History of repeated strokes with stepwise
progression of parkinsonism, history of repeated head injury, history of definite
encephalitis, prominent gait imbalance early in the course (< 5 years), dementia, known
severe anemia (hematocrit <30), history of kidney disease and/or current or past glomerular
filtration rate (GFR) <60 possibly indicative of kidney disease, or a serious comorbidity
that may interfere with participation in the study.