Neuroimaging of Diet in ADHD: Phase I
| Status: | Completed |
|---|---|
| Conditions: | Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 9 - 12 |
| Updated: | 2/7/2015 |
| Start Date: | May 2013 |
| End Date: | December 2014 |
| Contact: | Steven R Pliszka, MD |
| Email: | pliszka@uthscsa.edu |
Neuroimaging of Diet and Medication in the Treatment of ADHD
Children with Attention Deficit Hyperactivity Disorder (ADHD) aged 9-12 years of age will be
placed on a restriction diet for a 5 week period. Children will be randomized to either
receive daily snacks that conform to the diet or will violate the diet (Ruse diet) in a
double blind fashion. It is hypothesized that children who are consistently on the
restricted diet (relative to those on the ruse diet) will show improvements in ADHD
symptoms.
placed on a restriction diet for a 5 week period. Children will be randomized to either
receive daily snacks that conform to the diet or will violate the diet (Ruse diet) in a
double blind fashion. It is hypothesized that children who are consistently on the
restricted diet (relative to those on the ruse diet) will show improvements in ADHD
symptoms.
The ADHD rating scale (RS) will be the principal behavioral outcome measure. We hypothesize
that children on restriction diet will have significantly lower ADHD RS scores after 5 weeks
relative to the Ruse diet group. In addition children will undergo functional magnetic
resonance imaging (fMRI) at baseline and again at 5 weeks. Children will perform a flanker
task known to engage the dorsolateral prefrontal cortex (DLPFC) and the anterior cingulate
cortex (ACC) during attention tasks. The children will also perform will look at pictures
of appealing and unappealing food and rate whether they would like to eat it or not. This
task is known to activate the ventral striatum (VS) (reward processing). A secondary
hypothesis is whether children on the restricted diet will show changes in activity and
connectivity of areas (DLPFC, ACC, VS) relative to those on the Ruse diet.
that children on restriction diet will have significantly lower ADHD RS scores after 5 weeks
relative to the Ruse diet group. In addition children will undergo functional magnetic
resonance imaging (fMRI) at baseline and again at 5 weeks. Children will perform a flanker
task known to engage the dorsolateral prefrontal cortex (DLPFC) and the anterior cingulate
cortex (ACC) during attention tasks. The children will also perform will look at pictures
of appealing and unappealing food and rate whether they would like to eat it or not. This
task is known to activate the ventral striatum (VS) (reward processing). A secondary
hypothesis is whether children on the restricted diet will show changes in activity and
connectivity of areas (DLPFC, ACC, VS) relative to those on the Ruse diet.
Inclusion Criteria:
- Age 9-12 years
- Meets criteria for Attention Deficit Hyperactivity Disorder
- Parent must agree to use Study Diet Manual
Exclusion Criteria:
- Any Axis I psychiatric disorder other than Oppositional Defiant Disorder or Anxiety
Disorder not requiring psychopharmacological management
- Not currently on any pharmacological agent other than medication for ADHD
We found this trial at
1
site
4502 Medical Drive
San Antonio, Texas 78284
San Antonio, Texas 78284
(210) 567-7000
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
Click here to add this to my saved trials
