TAK-875 (Fasiglifam) in Combination With Sitagliptin in Adults With Type 2 Diabetes

The drug being tested in this study is called TAK-875 (fasiglifam). Fasiglifam is being
tested to treat people who have type 2 diabetes mellitus and are currently taking
sitagliptin (with or without metformin). This study will evaluate glycemic control in people
who take fasiglifam plus sitagliptin compared with placebo plus sitagliptin.

The study will enroll approximately 390 patients. Participants will be randomly assigned (by
chance, like flipping a coin) to one of the three treatment groups—which will remain
undisclosed to the patient and study doctor during the study (unless there is an urgent
medical need; all participants will be on 100 mg sitagliptin and may or may not be on
metformin background treatment):

- fasiglifam 25 mg

- fasiglifam 50 mg

- Placebo (dummy inactive pill) - this is a tablet that looks like the study drug but has
no active ingredient All participants will be asked to take one tablet at the same time
each day throughout the study.

This multi-centre trial will be conducted in North America and Latin America. The overall
time to participate in this study is approximately 38 weeks. Participants will make 15
visits to the clinic.

Inclusion Criteria:

1. In the opinion of the investigator, the participant is capable of understanding and
complying with protocol requirements.

2. The participant or, when applicable, the participant's legally acceptable
representative signs and dates a written, informed consent form and any required
privacy authorization prior to the initiation of any study procedures.

3. The participant is male or female and aged 18 years or older with a historical
diagnosis of T2DM.

4. The participant meets one of the following criteria:

- The participant has an HbA1c between 7.5% and 10.5%, inclusive and has been
taking a stable dose of sitagliptin 100 mg for at least 8 weeks, with or without
metformin, prior to the Screening Visit. A participant who is taking metformin
must have received a stable daily dose (≥1500 mg or documented maximum tolerated
dose [MTD]) for at least 8 weeks before Screening. This participant will enter
the 2-week single-blind Placebo Run-In Period according to Study Schedule A, or;

- The participant has an HbA1c between 7.5% and 10.5%, inclusive and has been
taking any other DPP-IV inhibitor (with or without metformin) for at least 8
weeks prior to the Screening Visit. A participant who is taking metformin must
have received a stable daily dose (≥1500 mg or documented MTD) for at least 8
weeks before Screening. This participant will enter the 8-week Switching Period
according to Study Schedule B. Following this 8-week period, the participant
must qualify for all Inclusion/Exclusion Criteria prior to entering the 2-Week
Placebo Run-in Period by completing the Week ( 3) procedures including having an
HbA1c level between 7.5% and 10.5%.

Note: An enrollment cap may be applied to ensure no more than approximately 20% of
randomized participants are receiving a DPP-IV inhibitor without metformin at
baseline.

5. The participant has had no treatment with antidiabetic agents other than DPP-IV
inhibitors and metformin within 2 months prior to Screening (Exception: if a
participant has received other antidiabetic therapy for ≤7 consecutive days within
the 2 months prior to Screening).

6. The participant has a body mass index (BMI) ≤45 kg/m2 at Screening.

7. Participants regularly using other, non-excluded medications must be on a stable dose
for at least 4 weeks prior to screening. However, PRN (as needed) use of prescription
or over-the-counter medication is allowed at the discretion of the investigator.

8. A female participant of childbearing potential who is sexually active with a
nonsterilized male partner agrees to routinely use adequate contraception from
signing of the informed consent throughout the duration of the study and for 30 days
after the last dose of study drug.

9. The participant is able and willing to monitor glucose with a home glucose monitor
and consistently record his or her own blood glucose concentrations and complete
participant diaries.

Exclusion Criteria:

1. Has received any investigational compound within 30 days prior to Screening or has
received an investigational antidiabetic drug within 3 months prior to Screening.

2. Has been randomized into a previous TAK-875 study.

3. Is an immediate family member, study site employee, or is in a dependent relationship
with a study site employee who is involved in conduct of this study (eg, spouse,
parent, child, or sibling; biological or legally adopted) or may consent under
duress.

4. Donated or received any blood products within 12 weeks prior to Screening or is
planning to donate blood during the study.

5. Has a hemoglobin ≤12 g/dL (≤120 gm/L) for males and ≤10 g/dL (≤100 gm/L) for females
at the Screening Visit.

6. Has a systolic blood pressure ≥160 mm Hg or diastolic pressure ≥95 mm Hg at Screening
(If the participant meets this exclusion criteria, the assessment may be repeated
once at least 30 minutes after the initial measurement and a decision will be made
based on the second measurement).

7. Has history of cancer that has been in remission for <5 years prior to Screening.
(Exception: A history of basal cell carcinoma or stage 1 squamous cell carcinoma of
the skin is allowed.)

8. Has alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) levels
>2.0x the upper limit of normal (ULN) at Screening.

9. Has a total bilirubin level greater than the ULN at Screening. Exception: if a
participant has documented Gilbert's Syndrome, they will be allowed with an elevated
bilirubin level per the investigator's discretion.

10. Has a serum creatinine ≥1.5 mg/dL (≥133 μmol/L) [males] and ≥1.4 mg/dL (≥124 μmol/L)
[females] and/or estimated glomerular filtration rate (GFR) <60 mL/min/1.73m^2 at
Screening.

11. Has uncontrolled thyroid disease.

12. Has a history of laser treatment for proliferative diabetic retinopathy within 6
months prior to Screening.

13. Has had gastric banding or gastric bypass surgery within one year prior to Screening.

14. Has a known history of infection with human immunodeficiency virus (HIV), Hepatitis B
virus (HBV), or Hepatitis C virus (HCV).

15. Had coronary angioplasty, coronary stent placement, coronary bypass surgery,
myocardial infarction, unstable angina pectoris, clinically significant abnormal
electrocardiogram (ECG), cerebrovascular accident or transient ischemic attack within
3 months prior to or at Screening.

16. Has a history of pancreatitis.

17. Has a history of hypersensitivity, allergies or has had an anaphylactic reaction(s)
to any component of TAK-875 as well as sitagliptin.

18. Has a history of drug abuse (defined as illicit drug use) or a history of alcohol
abuse within 2 years prior to Screening.

19. Received excluded medications prior to the Screening Visit or is expected to receive
excluded medications.

20. If female, is pregnant (confirmed by laboratory testing, ie, serum/urine human
chorionic gonadotropin (hCG), in females of childbearing potential) or lactating or
intending to become pregnant before, during, or within 1 month after participating in
this study; or intending to donate ova during such time period.

21. Is unable to understand verbal or written English or any other language for which a
certified translation of the approved informed consent is available.

22. Has any other physical or psychiatric disease or condition that in the judgment of
the investigator may affect life expectancy or may make it difficult to successfully
manage and follow the participant according to the protocol.