Comparing Complete Remission After Treatment With Selumetinib/Placebo in Patient With Differentiated Thyroid Cancer
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cancer, Cancer, Endocrine |
| Therapuetic Areas: | Endocrinology, Oncology |
| Healthy: | No |
| Age Range: | 18 - 127 |
| Updated: | 12/29/2018 |
| Start Date: | August 27, 2013 |
| End Date: | April 5, 2019 |
A Randomised, Double Blind Study to Compare the Complete Remission Rate Following a 5-Week Course of Selumetinib or Placebo and Single Dose Adjuvant Radioactive Iodine Therapy in Patients With Differentiated Thyroid Cancer
The study is designed to evaluate the clinical efficacy, safety and tolerability of
selumetinib with radioactive iodine therapy in patients with differentiated thyroid cancer.
selumetinib with radioactive iodine therapy in patients with differentiated thyroid cancer.
A Randomised, Double Blind Study to Compare the Complete Remission Rate Following a 5-Week
Course of Selumetinib or Placebo and Single Dose Adjuvant Radioactive Iodine Therapy in
Patients with Differentiated Thyroid Cancer.
Course of Selumetinib or Placebo and Single Dose Adjuvant Radioactive Iodine Therapy in
Patients with Differentiated Thyroid Cancer.
Inclusion Criteria:
Differentiated thyroid cancer Tumor >4 cm, or Gross extra-thyroid extension, or 1 lymph
node >1 cm, or 5 or more lymph nodes of any size Previous thyroidectomy Must be able to
receive radioactive iodine therapy Must be able to receive Thyroid Stimulating Hormone
suppression
Exclusion criteria:
Metastaic disease Anaplastic thyroid cancer, medullary thyroid cancer or Hurthle cell
carcinoma Presence of anti-Tg antibodies Previous treatment with any radiation Unresolved
toxicity ≥ common terminology criteria for adverse event Grade 2
We found this trial at
16
sites
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