Study of Intravenous Ceftolozane/Tazobactam Compared to Piperacillin/Tazobactam in Ventilator-Associated Pneumonia
| Status: | Terminated |
|---|---|
| Conditions: | Pneumonia |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/18/2018 |
| Start Date: | June 14, 2013 |
| End Date: | December 8, 2013 |
A Multicenter, Open-Label, Randomized Study to Compare the Safety and Efficacy of Intravenous Ceftolozane/Tazobactam With That of Piperacillin/Tazobactam in Ventilator Associated Pneumonia
This is a Phase 3, multicenter, prospective, randomized, open-label, study to compare the
safety and efficacy of intravenous (IV) ceftolozane/tazobactam with that of IV
piperacillin/tazobactam in the treatment of ventilator-associated pneumonia (VAP) in adult
participants .
safety and efficacy of intravenous (IV) ceftolozane/tazobactam with that of IV
piperacillin/tazobactam in the treatment of ventilator-associated pneumonia (VAP) in adult
participants .
Key Inclusion Criteria:
- Participant has received mechanical ventilation for > 48 hours
- Acute Physiology and Chronic Health Evaluation (APACHE) II score of 11-35
- Presence of a new or progressive infiltrate on chest x-ray
- Presence of clinical criteria consistent with VAP
Key Exclusion Criteria:
- History of moderate or severe hypersensitivity reactions to beta-lactam antibiotics
- Known end stage renal disease or requirement for dialysis
We found this trial at
12
sites
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