High Resolution Retinal Imaging
| Status: | Recruiting |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 7 - Any |
| Updated: | 8/4/2018 |
| Start Date: | May 2013 |
| End Date: | December 2020 |
| Contact: | Jessica IW Morgan, PhD |
| Email: | jwmorgan@pennmedicine.upenn.edu |
| Phone: | 215-614-4196 |
Studying the morphology and function of the normal and diseased retina in vivo is needed for
advancing the detection, diagnosis, and treatment of retinal disease. This protocol uses an
adaptive optics scanning laser ophthalmoscope (AOSLO) to image the normal and diseased retina
with individual cellular resolution non-invasively. The primary objective of this study is to
obtain and analyze high-resolution images of the retina, in particular by imaging the cone
photoreceptor mosaic, the retinal vasculature and other retinal layers. The study design will
involve case-control studies, where cases are followed over time. Subjects age 7 and older
may be invited to participate. The main research procedure involves retinal imaging with the
AOSLO. The primary endpoint is the observation of differences in retinal images between
subjects with and without retinal diseases. These changes will be quantified by examining the
cell density, size, spacing and regularity of the cone photoreceptor mosaic, as well as
examining the differences between other retinal layers.
advancing the detection, diagnosis, and treatment of retinal disease. This protocol uses an
adaptive optics scanning laser ophthalmoscope (AOSLO) to image the normal and diseased retina
with individual cellular resolution non-invasively. The primary objective of this study is to
obtain and analyze high-resolution images of the retina, in particular by imaging the cone
photoreceptor mosaic, the retinal vasculature and other retinal layers. The study design will
involve case-control studies, where cases are followed over time. Subjects age 7 and older
may be invited to participate. The main research procedure involves retinal imaging with the
AOSLO. The primary endpoint is the observation of differences in retinal images between
subjects with and without retinal diseases. These changes will be quantified by examining the
cell density, size, spacing and regularity of the cone photoreceptor mosaic, as well as
examining the differences between other retinal layers.
Inclusion Criteria:
- Males or females age 7 years or older.
- Parental/guardian permission (informed consent) and if appropriate, child assent.
Child subjects age 7-17 must give assent.
- Reasonable compliance with an imaging protocol as determined by the study personnel.
Exclusion Criteria:
- Individuals that are at risk to acute glaucoma.
- Individuals that are photophobic and experience adverse psychological reactions to
flashes of light.
- Ocular opacities, high refractive error, and high frequency of nystagmus as determined
by the study team.
We found this trial at
1
site
3451 Walnut St
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Phone: 215-614-4196
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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