Study to Examine the Effect of Gastric Bypass Surgery on Venlafaxine ER Blood Levels

Inclusion criteria:

- Approved to undergo Roux-en-Y gastric bypass surgery (cost of surgery is NOT included in
the study)

Exclusion criteria:

- Pregnant

- Allergy to venlafaxine or desvenlafaxine

- Psychiatric hospitalization within the prior 12 months

- Active professional treatment for recent substance abuse within 12 months of
abstinence

- Ongoing psychologic issues, such as personality disorders, difficulties as a trauma
survivor, or difficulties with depression unless a stable, documented course of
treatment by a licensed mental health professional is available

- Current use of any of the following medications/supplements: 5-hydroxytryptophan,
almotriptan, amitriptyline, amoxapine, amoxicillin-clavulanate,
amphetamine-dextroamphetamine, atazanavir, bupropion, cinacalcet, citalopram,
clarithromycin, clomipramine, desipramine, desvenlafaxine, dextroamphetamine,
dextromethorphan, doxepin, duloxetine, eletriptan, entacapone, escitalopram,
fluoxetine, fluvoxamine, frovatriptan, haloperidol, imipramine, isocarboxazid,
itraconazole, jujube seed extract, linezolid, maprotiline, methylene blue,
metoclopramide, metoprolol, milnacipran, mirtazapine, naratriptan, nefazodone,
nelfinavir, nortriptyline, paroxetine, phenelzine, procarbazine, protriptyline,
quinidine, rasagiline, ritonavir, rizatriptan, saquinavir, selegiline, sertraline,
St. John's wort, sumatriptan, tapentadol, terbinafine, toremifene, tramadol,
tranylcypromine, trazodone, trifluoperazine, trimipramine, tryptophan, L-tryptophan,
venlafaxine, vilazodone, zolmitriptan