ACL Repair and Multimodal Analgesia

Inclusion Criteria:

- Patients of orthopedic surgeons on the study team scheduled for ACL repair using
hamstring graft from the same leg will be considered for inclusion in this study.
Other inclusion criteria are as follows:

1. American Society of Anesthesiologists (ASA) physical status 1-3

2. 18-55 years of age, inclusive

3. BMI of < 40 kg/m2.

4. Consents to general anesthesia and pre-operative femoral nerve block for case.

Exclusion Criteria:

Exclusion criteria include:

1. Any contraindication to a femoral nerve block

2. Allergy to local anesthetics, nonsteroidal anti-inflammatory medications,
ketamine, acetaminophen, hydromorphone, oxycodone

3. Peripheral or central nervous system disease

4. Renal or hepatic impairment

5. History of opioid dependence or current regular narcotic use

6. Significant psychiatric disease

7. Pregnancy or lactation (by verbal report)

8. Seizure Disorder

9. History of post- operative nausea and vomiting

10. Latex allergy

11. Clinically significant cardiac or pulmonary disease