Dexamethasone for Post Cesarean Delivery Analgesia
| Status: | Completed |
|---|---|
| Conditions: | Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 7/11/2015 |
| Start Date: | March 2013 |
| End Date: | February 2014 |
| Contact: | Unyime Ituk, MD |
| Email: | Unyime-Ituk@Uiowa.edu |
| Phone: | 319-356-2633 |
The Effect of a Single Intraoperative Dose of Dexamethasone in Combination With Intrathecal Morphine for Post Cesarean Delivery Analgesia
The purpose of this study is to assess the effectiveness intravenous (IV) dexamethasone when
used as part of a multimodal regimen to manage post cesarean delivery pain.
We hypothesize that a single dose of IV dexamethasone administered, as part of a multimodal
analgesia after spinal anesthesia will significantly reduce post cesarean delivery opioid
consumption and pain
used as part of a multimodal regimen to manage post cesarean delivery pain.
We hypothesize that a single dose of IV dexamethasone administered, as part of a multimodal
analgesia after spinal anesthesia will significantly reduce post cesarean delivery opioid
consumption and pain
After the subjects consent to participate in the study they will be transferred to the
operating room for their scheduled cesarean delivery. They will have their routine spinal
anesthesia with the dosages of drugs used standardized, and a standardized regimen to manage
hypotension. After delivery of the baby the subjects will be administered either the study
drug or placebo depending on the randomization. The subjects will then be prescribed a
standard post-operative analgesia regimen. The subjects will then be interviewed at 12,24
and 48 hours post cesarean delivery. During the interview the subjects will be asked to rate
their pain, nausea and vomiting and pruritus. They will also be asked to rate their quality
of recovery from the surgery using Quality of Recovery-40 questionnaire. The subjects will
be contacted 6 months after the study to rate their pain using a Short-Form McGill Pain
Questionnaire
operating room for their scheduled cesarean delivery. They will have their routine spinal
anesthesia with the dosages of drugs used standardized, and a standardized regimen to manage
hypotension. After delivery of the baby the subjects will be administered either the study
drug or placebo depending on the randomization. The subjects will then be prescribed a
standard post-operative analgesia regimen. The subjects will then be interviewed at 12,24
and 48 hours post cesarean delivery. During the interview the subjects will be asked to rate
their pain, nausea and vomiting and pruritus. They will also be asked to rate their quality
of recovery from the surgery using Quality of Recovery-40 questionnaire. The subjects will
be contacted 6 months after the study to rate their pain using a Short-Form McGill Pain
Questionnaire
Inclusion Criteria:
- English Speaking
- Non-laboring women
- Scheduled Elective Cesarean section under spinal anesthesia
- American Society of Anesthesiologists I-II physical status
Exclusion Criteria:
- Contraindications to spinal anesthesia
- allergy to study medication
- patients with allergy to morphine
- patients with uncontrolled hypertension
- history of peptic ulcer disease
- liver cirrhosis
- diabetes mellitus
- glaucoma
- known IV drug abusers
- patients with chronic pain or on long term opioids
- patients administered steroids in the past week
- women with fetuses having known congenital abnormalities
- psychiatric illness such that they are unable to comprehend or participate in study
questions
- patients on antiviral medications or live virus vaccines would also be excluded.
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