A Pharmacokinetic Study of Baricitinib in Participants With Liver Disease

Inclusion Criteria for ALL Participants:

- Male participants agree to use 2 reliable methods of birth control with female
partners of child-bearing potential during the study and for at least 3 months
following the last dose of study drug

- Women not of child-bearing potential due to surgical sterilization (at least 6 weeks
after surgical bilateral oophorectomy with or without hysterectomy or at least 6
weeks after confirmed tubal occlusion/tubal ligation) confirmed by medical history,
or menopause

- Menopausal women with spontaneous amenorrhea for at least 12 months, not induced by a
medical condition and by medications and have a follicle-stimulating hormone (FSH)
level greater than 40 milli-international units per milliliter (mIU/mL) (unless the
participant is taking hormone replacement therapy [HRT])

- Have a body mass index of 18.5 to 40.0 kilograms per square meter (kg/m^2) inclusive
at the time of screening

Additional Inclusion Criteria for Healthy Participants:

- Are overtly healthy participants, have normal hepatic function and have stable
chronic medical conditions

- Have clinical laboratory test results within normal reference range for the
population or investigator site, or results with acceptable deviations that are
judged to be not clinically significant by the investigator

Additional Inclusion Criteria for Hepatically Impaired Participants:

- Participants with hepatic impairment classified as Child-Pugh score A or B (mild
[Group 3, if enrolled] or moderate [Group 2] impairment, respectively). Must have a
diagnosis of chronic hepatic impairment (greater than 6 months), with no clinically
significant changes within 90 days prior to study drug administration (Day 1).
Participants may have mild stable baseline medical conditions for which neither the
condition nor treatments received would negatively impact the health of the
participant or study conduct

- Clinical laboratory test results with deviations that are judged by the investigator
to be compatible with the hepatic impairment of the participant, or of no additional
clinical significance for this study

Exclusion Criteria for ALL Participants:

- Have received, within the last 30 days, an investigational product as part of a
clinical trial, or are concurrently enrolled in any other type of medical research
judged not to be scientifically or medically compatible with this study

- Persons who have previously completed or withdrawn from study investigating
baricitinib, and have previously received the investigational product

- Women with a positive pregnancy test or who are lactating

- Have a current or recent history (less than 30 days prior to screening and/or less
than 45 days prior to admission to the clinical research unit) of a clinically
significant bacterial, fungal, parasitic, viral (excluding rhinopharyngitis), or
mycobacterial infection

- Have had symptomatic herpes zoster or herpes simplex infection within 90 days prior
to the first dose

- Show evidence of human immunodeficiency virus (HIV) infection and/or positive human
HIV antibodies

- Have been exposed to a live vaccine within 12 weeks prior to the first dose or
expected to need/receive a live vaccine (including herpes zoster vaccination) during
the course of the study

Additional Exclusion Criteria for Healthy Participants:

- Show evidence of acute or chronic liver disease

- Show evidence of hepatitis B and/or positive hepatitis B and/or positive hepatitis B
surface antigen

- Show evidence of hepatitis C and/or positive hepatitis C antibody

- Intend to use over-the-counter or prescription medication and/or herbal supplements
within 14 days prior to dosing and during the study

Additional Exclusion Criteria for Liver Impaired Participants:

- Have creatinine clearance less than or equal to 50 milli-liter per minute (mL/min)
using the Cockcroft and Gault formula

- Show evidence of spontaneous bacterial peritonitis within 6 month of dosing

- Have had variceal bleeding within 3 months of check in

- Show evidence of severe hyponatremia (sodium less than 120 millimolar per liter
(mmol/L)

- Have severe encephalopathy(Grade 3 to 4)

- Have moderate to severe ascites (moderately hepatically impaired participants only)

- Show presence of a portal shunt

- Have hemoglobin less than 9.0 grams per deciliter (g/dL)

- Have serum bilirubin greater than 15 milligrams per deciliter (mg/dL)