Validation of Lower Body Negative Pressure (LBNP) Model of Human Hemorrhage in Trauma Patients
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | Any - 89 |
| Updated: | 2/10/2019 |
| Start Date: | October 2013 |
| End Date: | December 2019 |
Validation of LBNP Model of Human Hemorrhage in Trauma Patients
Lower body negative pressure (LBNP) is a laboratory model used to study hemorrhage in humans.
The investigators hypothesize that the physiologic changes that occur with application of
LBNP mimic those observed in bleeding and hemodynamically unstable trauma patients, and that
LBNP is a truly valid model of human hemorrhage.
The investigators hypothesize that the physiologic changes that occur with application of
LBNP mimic those observed in bleeding and hemodynamically unstable trauma patients, and that
LBNP is a truly valid model of human hemorrhage.
Specific aims:
1. Compare physiologic waveform data obtained from bleeding and hemodynamically unstable
trauma patients to existing data collected from LBNP subjects.
2. Determine the accuracy of LBNP in approximating the physiologic changes that occur in
bleeding and hemodynamically unstable trauma patients.
1. Compare physiologic waveform data obtained from bleeding and hemodynamically unstable
trauma patients to existing data collected from LBNP subjects.
2. Determine the accuracy of LBNP in approximating the physiologic changes that occur in
bleeding and hemodynamically unstable trauma patients.
Inclusion Criteria:
- age: 31 days - 89 years
- patients cared for in the Emergency Department (ED), Operating Room (OR), or the
Intensive Care Unit (ICU) at Denver Health Medical Center, Children's Hospital
Colorado and San Antonio Military Medical Center
- Patients with report of physical trauma within 24 hours of presentation at the
hospital.
Exclusion Criteria:
- pregnant patients
- incarcerated patients
- patients who object at any time to participating in the study
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