Treatment for Relapsed/Refractory AML Based on a High Throughput Drug Sensitivity Assay

PRIMARY OBJECTIVES:

I. To obtain results from a high throughput drug sensitivity assay within 10 days, procure
drug within 14 days and initiate treatment within 21 days.

SECONDARY OBJECTIVES:

I. To achieve a response (cytoreduction or at least partial response) greater that than
expected for comparable refractory patient populations with other salvage regimens.

OUTLINE:

A patient receives a drug intervention based on the results of a high throughput sensitivity
assay. This assay best matches a drug to the patient's disease.

Inclusion Criteria:

- Diagnosis of acute myeloid leukemia by World Health Organization (WHO) criteria
(except acute promyelocytic leukemia), acute leukemias of ambiguous lineage by WHO
criteria, or myelodysplastic syndrome refractory anemia with excess blasts (RAEB)-2 by
WHO classification or advanced myeloproliferative neoplasm with >= 10% blasts in the
bone marrow or peripheral blood, including chronic myelomonocytic leukemia (CMML)-2 by
WHO classification who have failed 2 inductions at initial diagnosis or failed >= 2
salvage regimens for relapsed acute myeloid leukemia (AML)

- Patients who have had a 1st remission for >= 1 year must have received cytotoxic
chemotherapy as a salvage regimen

- Eastern Cooperative Oncology Group (ECOG) performance status 0 - 3

- Expectation that we can obtain about 100 million blasts from blood and/or marrow (for
example, circulating blast count of 5,000 or greater)

- Bilirubin =< 1.5 x institutional upper limit of normal (IULN) unless elevation is
thought to be due to Gilbert's syndrome, hemolysis, or hepatic infiltration by the
hematologic malignancy

- Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) and
serum pyruvate glutamate transaminase (SPGT) (alanine aminotransferase [ALT]) =< 2.5 x
IULN, unless elevation in thought to be due to hepatic infiltration by the hematologic
malignancy

- Alkaline phosphatase =< 2.5 X ULN

- Serum creatinine =< 2.0 mg/dL

- Stable or improving on appropriate antimicrobial therapy for infection, without
ongoing fever

- Informed consent

- Willing to use contraception

Exclusion Criteria:

- No other concomitant treatment for leukemia

- No other active cancer that requires systemic chemotherapy or radiation

- Significant organ compromise that will increase risk of toxicity or mortality

- Pregnancy or lactation