A Study of LY3023703 Testing Pain Relief After Wisdom Teeth Removal
Status: | Completed |
---|---|
Conditions: | Chronic Pain |
Therapuetic Areas: | Musculoskeletal |
Healthy: | No |
Age Range: | 18 - 45 |
Updated: | 12/16/2017 |
Start Date: | June 2013 |
End Date: | October 2013 |
Evaluation of the Acute Analgesic Efficacy of a Single Dose of LY3023703 in Patients With Postsurgical Dental Pain: A Parallel, Double-Blind, Randomized, Placebo and Positive Control Study
The main purpose of this study is to test if a single dose of LY3023703 relieves pain after
wisdom teeth removal. The study will last about one week for each participant, not including
screening.
wisdom teeth removal. The study will last about one week for each participant, not including
screening.
Inclusion Criteria:
- Have at least 2 third molars which are clinically indicated for extraction. At least 1
molar should be a mandibular third molar with partial or complete bony impaction
- Are overtly healthy as determined by medical history and limited physical examination
Exclusion Criteria:
- Have chronic pain [for example (e.g.), fibromyalgia] or are experiencing episodic pain
not related to the wisdom teeth (e.g., migraine pain) that could affect pain
measurements as judged by the investigator
- Have temporomandibular joint disease or other condition which could affect pain
processing or sensation, affect recovery from dental surgery, or otherwise affect
ability to assess pain signal, in the opinion of the investigator
- Have substantial anxiety regarding dental or medical procedures as measured by the
Corah Dental Anxiety Scale
- Are currently using or have recently used drugs that may confound assessment of the
inflammatory response or pain including, but not limited to, nonsteroidal
anti-inflammatory drugs (NSAIDs), aspirin and other analgesics, antihistamines,
steroids, antidepressants, attention-enhancing drugs, or herbal supplements
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