Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | May 2013 |
| End Date: | January 2016 |
Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque -- A Pilot Study
This will be a pilot study of 9 patients undergoing standard-of-care clinically indicated
carotid endarterectomy. The nine patients will receive an injection of Indocyanine green
(ICG) at a dose of 0.25 mg/kg (maximum 25 mg) as an intravenous bolus.
Immediately following endarterectomy, the resected specimen will be immersed in normal
saline. Ex vivo fluorescence reflectance imaging (FRI) and immunohistochemistry will be
performed.
The investigators hypothesize that compared to controls, ICG-injected patients will
demonstrate increased ex vivo and microscopic ICG fluorescence signal within areas of
plaque.
carotid endarterectomy. The nine patients will receive an injection of Indocyanine green
(ICG) at a dose of 0.25 mg/kg (maximum 25 mg) as an intravenous bolus.
Immediately following endarterectomy, the resected specimen will be immersed in normal
saline. Ex vivo fluorescence reflectance imaging (FRI) and immunohistochemistry will be
performed.
The investigators hypothesize that compared to controls, ICG-injected patients will
demonstrate increased ex vivo and microscopic ICG fluorescence signal within areas of
plaque.
Inclusion Criteria:
- Consecutive patients scheduled for elective carotid endarterectomy at Massachusetts
General Hospital
- Age > 18 years of age.
- Signed informed consent.
Exclusion criteria:
- Hemodynamic instability
- Any history of iodide allergy
- Any history of renal failure (estimated Glomerular Filtration Rate (eGFR) <50
ml/min/1.73 m2)
- Any history of liver failure
- Any history of bleeding diathesis
- Any history of cerebral vascular accident in the preceding 3 months
- Pregnant or lactating females.
- Hx of seafood allergy
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