The Effects of Altering Physical Activity on Cardiometabolic Health
| Status: | Completed |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 19 - 35 |
| Updated: | 4/21/2016 |
| Start Date: | March 2012 |
| End Date: | October 2014 |
The Effects of Altering Physical Activity on Endothelial Function, Glycemic Control, and the Blood Flow Response to an Oral Glucose Tolerance Test.
The effects of physical inactivity on variations in blood glucose and vascular health are
not fully understood. The purpose of this study is to determine if an acute transition from
physical activity to inactivity alters vascular health. Specifically, the investigators wish
to examine in healthy, lean physically active individuals (obtaining greater than 10,000
steps/day) if decreasing physical activity (obtaining less than 5,000 steps/day) will alter
blood flow following a meal a marker of vascular health. Furthermore, the investigators wish
to examine if a one day return to physical activity (obtaining >10,000 steps/day) can
restore the detrimental effects on blood flow following a meal.
not fully understood. The purpose of this study is to determine if an acute transition from
physical activity to inactivity alters vascular health. Specifically, the investigators wish
to examine in healthy, lean physically active individuals (obtaining greater than 10,000
steps/day) if decreasing physical activity (obtaining less than 5,000 steps/day) will alter
blood flow following a meal a marker of vascular health. Furthermore, the investigators wish
to examine if a one day return to physical activity (obtaining >10,000 steps/day) can
restore the detrimental effects on blood flow following a meal.
Herein, we tested the hypothesis that an acute reduction in daily activity (from >10,000 to
<5,000 steps/day) for 5 days in healthy individuals reduced meal-stimulated blood flow and
if a 1 day return to activity improved this outcomes.
<5,000 steps/day) for 5 days in healthy individuals reduced meal-stimulated blood flow and
if a 1 day return to activity improved this outcomes.
Inclusion Criteria:
- BMI: less than 30 kg/m2
- Physically active: exercise greater than 60mins per week
Exclusion Criteria:
- smoking
- type 2 diabetes
- Underlying conditions that limit ability to exercise safely
- Recent weight gain or loss(> 5% of body weight in 3 months)
- Recent (< 3 mo) changes in medication use or dose
- Pregnancy
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University of Missouri T he University of Missouri was founded in 1839 in Columbia, Mo.,...
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