Effects of Resveratrol on Endothelial Function in Type 2 Diabetes Mellitus
| Status: | Completed |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 21 - 75 |
| Updated: | 4/17/2018 |
| Start Date: | January 1, 2013 |
| End Date: | July 2016 |
Randomized Crossover Study of The Effects of Resveratrol on Endothelial Function in Subjects With Type 2 Diabetes Mellitus
The present study is designed to test the hypothesis that resveratrol supplementation will
improve the function of the endothelium in patients with type 2 diabetes mellitus.
The function of the endothelium will be tested with a non-invasive technique that uses
ultrasound to measure the amount of dilation that occurs in the brachial artery following
5-minute cuff occlusion. To help us understand potential mechanisms of benefit, we will also
collect blood, urine, and cell samples and test the effects of treatment on protein
expression, nitric oxide production, and function of mitochondria.
improve the function of the endothelium in patients with type 2 diabetes mellitus.
The function of the endothelium will be tested with a non-invasive technique that uses
ultrasound to measure the amount of dilation that occurs in the brachial artery following
5-minute cuff occlusion. To help us understand potential mechanisms of benefit, we will also
collect blood, urine, and cell samples and test the effects of treatment on protein
expression, nitric oxide production, and function of mitochondria.
Inclusion Criteria:
- Male and female subjects
- Age over 21 years old
- Body mass index less than 38 kg/m2
- Clinical stable type 2 diabetes mellitus
Exclusion Criteria:
- Women who are lactating or pregnant
- Treatment with an investigations product within 30 days of screening
- Clinically evident major illness of other organ systems, including cancer, renal
failure, or other conditions in the opinion of the investigators that would make
clinical study inappropriate
- Liver transaminase levels greater than 3 times the upper limit of normal
- History of psychological illness or condition that would interfere with the subject's
ability to understand the requirements of the study
- Vitamin supplements exceeding two times the recommended daily allowance
- Resveratrol or other dietary supplements except for a daily multivitamin
We found this trial at
1
site
1 Boston Medical Center Place
Boston, Massachusetts 02118
Boston, Massachusetts 02118
617.638.8000
Boston University Medical Center Boston Medical Center is an extraordinary community of health care providers...
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