Cryotherapy -BEATS-RF Ablation Trial
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/20/2019 |
| Start Date: | June 2013 |
| End Date: | June 2019 |
CryoSpray Ablation for Barrett's Esophagus After Treatment Failure With Serial RadioFrequency Ablation
The purpose of this study is to determine whether cryotherapy is effective in the treatment
of persistent high grade dysplasia (HGD) or early esophageal adenocarcinoma (IMCA) in
patients who have not responded to radiofrequency ablation (RFA).
of persistent high grade dysplasia (HGD) or early esophageal adenocarcinoma (IMCA) in
patients who have not responded to radiofrequency ablation (RFA).
Inclusion Criteria:
- Age > 18 years old
- Able to provide informed consent
- Patients with unifocal or multifocal BE with HGD or IMCA who have failed at least 2
serial RFA therapy.
- Patients who refused esophagectomy or deemed inoperable or whose BE dysplasia is not
amenable to endoscopic mucosal resection (EMR) treatment alone due to: (1) extensive
multifocal lesions (2) severe coagulopathy or any medical condition deemed high risk
for EMR (3) patient refuses EMR
- Patients with a nodular BE lesions may undergo clinically-indicated EMR and still be
eligible for enrollment as long as they have BE-HGD lesion/s that are still candidate
for ablative treatment
Exclusion Criteria:
- Age younger than 18 years old
- Life expectancy less than 12 months
- Pregnancy
- Presence of esophageal varices
- Esophageal stricture precluding passage of an endoscope and suction tubing
- Any procedure that has impeded normal gastric emptying or limited gastric volume
distention, including but not limited to gastric bypass, stomach stapling,
gastrojejunostomy or any disease state has significantly reduced the elasticity in the
GI tract (e.g. Marfan's syndrome, Scleroderma or any Connective Tissue Disease)
- Esophageal cancer (T2 and above)
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