Vitamin D Supplementation for Bipolar Depression
| Status: | Completed |
|---|---|
| Conditions: | Depression, Psychiatric, Bipolar Disorder |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 6/21/2018 |
| Start Date: | June 2013 |
| End Date: | August 2015 |
Randomized Double-Blind Placebo-Controlled Pilot Study of Vitamin D Supplementation for the Treatment of Bipolar Depression
The purpose of this study is to whether vitamin d supplementation in those with low levels
may reduce depression symptoms in people experiencing bipolar depression.
may reduce depression symptoms in people experiencing bipolar depression.
Inclusion Criteria:
- Adults >18years old
- Bipolar disorder (I,II or NOS),
- MADRS Score>7 (mild),
- 25(OH)D level <30ng/ml (insufficient).
- able to take the prescribed vitamin D by mouth
Exclusion Criteria:
Systemic diseases such as:
- liver and kidney diseases,
- known parathyroid disorder,
- disorders of vitamin D metabolism,
- taking vitamin D replacement therapy,
- fat digestion disorder,
- diabetes mellitus,
- gi surgery
- If the serum calcium in the range 2.50-2.55 mmol L, inclusion required a serum PTH
below 5.0 pmol L-acute psychiatric urgency:
- active suicidality,
- acute psychosis,
- active substance use<6mo or
- pregnant or nursing females
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