Safety, Tolerability and Efficacy of ISIS-GCGRRx in Type 2 Diabetes

Inclusion Criteria:

- Male or female, age 18 to 75

- BMI greater than or equal to 25

- HbA1c greater than or equal to 7.5% and less than or equal to 10.5%

- Type 2 Diabetes Mellitus and on stable dose of oral metformin

- Agree to conduct home-based (fasted) blood glucose testing as directed

Exclusion Criteria:

- Clinically significant abnormalities in medical history or physical exam

- Show evidence of uncorrected hypothyroidism or hyperthyroidism hormone results

- History of renal transplantation or renal dialysis

- History of liver disease

- History of greater than 3 episodes of severe hypoglycemia within 6 months of
screening

- Use of oral anti-diabetic medication other than metformin within 3 months of
screening

- History of diabetic ketoacidosis

- Any other significant illness or condition that may interfere with the patient
participating or completing the study

- Inability or unwillingness to comply with protocol or study procedures