Cocoa Polyphenols and Postprandial Metabolism in Type 2 Diabetes
| Status: | Completed |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 21 - 60 |
| Updated: | 1/24/2018 |
| Start Date: | January 2012 |
| End Date: | December 2014 |
Postprandial Effects of Polyphenol-rich Cocoa Beverage on Glucose, Insulin, Lipids, Oxidative Stress and Inflammation in Type 2 Diabetic Patients
This study aims to investigate the postprandial effects of cocoa supplementation in glucose
and lipids, and surrogate markers of atherosclerosis in patients with type 2 diabetes. The
investigators aim to test the hypothesis that cocoa will lower high-fat mixed meal
breakfast-induced postprandial rise of glucose, lipids and markers of atherosclerosis in
patients with diabetes. Randomized cross-over controlled trial, in which participants will be
assigned to the placebo or cocoa group with breakfast meal. Patients with type 2
diabetes(n=25) will qualify for the study. The participants will be asked to consume 2 cups
cocoa or placebo beverage on 2 separate postprandial study days. Both groups will receive
high-fat mixed meal breakfast on each day. Blood draws and blood pressure (including HDI)
measurements will be conducted at fasting, 30 min, 1,2, 4 & 6 hours postprandial each day for
2 days.
and lipids, and surrogate markers of atherosclerosis in patients with type 2 diabetes. The
investigators aim to test the hypothesis that cocoa will lower high-fat mixed meal
breakfast-induced postprandial rise of glucose, lipids and markers of atherosclerosis in
patients with diabetes. Randomized cross-over controlled trial, in which participants will be
assigned to the placebo or cocoa group with breakfast meal. Patients with type 2
diabetes(n=25) will qualify for the study. The participants will be asked to consume 2 cups
cocoa or placebo beverage on 2 separate postprandial study days. Both groups will receive
high-fat mixed meal breakfast on each day. Blood draws and blood pressure (including HDI)
measurements will be conducted at fasting, 30 min, 1,2, 4 & 6 hours postprandial each day for
2 days.
Inclusion Criteria:
- clinical diagnosis of type 2diabetes
Exclusion Criteria:
- on insulin therapy
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