Patient Registry of Intrathecal Ziconotide Management(PRIZM)

Inclusion Criteria:

- Patient is at least 18 years of age at the time of study entry.

- Patient who has severe chronic pain, whom IT therapy is warranted, and who is
intolerant of, or refractory to other treatments, such as systemic analgesics,
adjunctive therapies, and/or IT morphine.

- Patient is planned to be initiated on IT PRIALT as the sole agent in the pump at a
participated site.

- Patient has not received PRIALT treatment administered continuously via Medtronic
SynchroMed® II pump within the past 30 days.

- Patient has a life expectancy >6 months as determined by the physician.

- Patient is able to read, understand, and voluntarily sign the IRB-approved informed
consent document prior to the performance of any study-specific procedures.

- Patient is able to understand and complete required assessments.

Exclusion Criteria:

- Patient has a known hypersensitivity to PRIALT or any of its formulation components.

- Patient has a pre-existing history of psychosis.

- Patient has infection at the microinjection site, uncontrolled bleeding diathesis, or
known spinal canal obstruction that impairs circulation of cerebrospinal fluid.

- Patient is being initiated with PRIALT in conjunction with other IT agents.

- Patients with any other concomitant treatment or medical condition that, in the
opinion of the clinician, would render IT administration hazardous.