Pilot Clinical Trial of ACTHar Gel 14 Days Subcutaneous (SQ)Versus ACTHar Gel Five Days SQ for the Treatment of MS Exacerbations

Evaluations and treatment will be administered as an outpatient in the Neurology Clinic.
Each subject will be seen for MS relapse or exacerbation in the Neurology Clinic during a
routine or semi-emergent visit. Patients will be offered an FDA approved treatment (ACTHar
Gel) for MS attacks under a standard 14 day SQ protocol (standard 14 day SQ protocol (80 IU
x 14 days) or a 5 day SQ protocol - (5 day subcutaneous protocol (80 IU x 5 days). Both
protocols are within package insert guidelines. The subjects will be evaluated for Extended
Disability Status Scales (EDSS), a standardized measure of clinical status in MS and the
initial visit and 28 days later (and 90 days later). We will compare the change in EDSS
outcomes between day 0 and day 28 (day 90) to determine if the 14 days is superior to 5 day
protocol may be clinically equivalent. Patients will also be evaluated for walking, upper
extremity function (9 hole peg test), cognition and vision.

Inclusion Criteria:

1. Adult male or female subjects with MS having a relapse (attack) or exacerbation of
MS. Acute symptomatic exacerbation of MS present for > 24 hours and < 14 days at
screening with new or worsening symptoms, and with signs referable to the symptoms in
the absence of a fever or active infection.

2. Diagnosis of a relapsing forms of multiple sclerosis before randomization as
determined by Poser or McDonald Criteria (standard MS diagnostic criteria).

3. Expanded disability status scale (EDDS) between 2 and 6.5, inclusive at entry.

4. Episodes include study neurologist or neuro-ophthalmologist diagnosed: acute optic
neuritis, cerebellar, brainstem dysfunction, myelitis, focal cerebral, and/or
definitive focal sensory dysfunction.

5. New objective clinical finding other than the sensory exacerbation or the
bowel/bladder signs alone. Sensory deficits alone will not qualify except for optic
neuritis.

6. Subjects may continue on their current immunomodulation therapy such as interferons,
glatiramer acetate, gilenya or natalizumab.

7. Identified patients must be between the ages of 18 and 55 years, inclusive.

8. Ability to understand and the willingness to sign a written informed consent
document.

Exclusion Criteria:

1. Subjects who are pregnant, or nursing.

2. Any patients treated with systemic corticosteroid use within one month of the index
episode at screening.

3. Prior use of immunosuppressive treatments within 90 days of index episode
(mitoxantrone, azathioprine, Cellcept, IVIg) or plasmapheresis.

4. Unable to perform timed 25 foot walk (ambulation Index), 9 HPT (9 hole peg test),
PASAT (Paced Auditory Serial Addition Test) 3.

5. Peripheral or cranial neuropathy as sole problem of acute episode.

6. Subjects with uncontrolled intercurrent illness including, but not limited to ongoing
or active infection, or psychiatric illness/social situations that would limit
compliance with study requirements.

7. History of any significant cardiac, gastrointestinal, hepatic, pulmonary, or renal
disease; immune deficiency; or other medical conditions that would preclude
corticosteroid therapy.

8. Subjects with clinical diagnosis of scleroderma, osteoporosis, systemic fungal
infections, ocular herpes simplex, recent surgery, history of or the presence of a
peptic ulcer, congestive heart failure, hypertension, or sensitivity to proteins of
porcine origin.

9. Primary Progressive Multiple Sclerosis (PPMS) (MS without attacks). -