Effects of Interrupting Sedentary Behavior on Metabolic and Cognitive Outcomes in Children
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 7 - 11 |
| Updated: | 2/2/2018 |
| Start Date: | June 26, 2013 |
| End Date: | January 29, 2018 |
Background:
- Some studies in adults have found that insulin and glucose blood levels are lower when a
long period of sitting is broken up with walking, compared to sitting without breaks. This
means that the body can better process sugars when there are walking breaks during the day.
Researchers want to know if this is also true for children. Some studies have found that
children s attention and memory might be better after exercise. Researchers want to know if
short walking breaks have the same effects.
Objectives:
- To understand if breaking up sitting with walking helps children s bodies better use sugars
and improves children s concentration.
Eligibility:
- Healthy children ages 7 to 11.
Design:
- Participants will be screened with a physical exam, medical history, exercise test,
picture vocabulary test, and medical tests including blood tests and X-rays.
- Participants will return for two 7-hour visits. In the month before the visits, they
will wear a physical activity monitor for one week so researchers know how active they
are. Once they will take the sitting only test and once the sitting breaks test.
- During the sitting only test, participants will sit for 3 hours.
- During the sitting breaks test, they will sit for 3 hours with 3-minute walking breaks
every 30 minutes.
- Both days, they will drink sugar water. Then the participants will have blood drawn from
a needle that is kept in place, and they will wear a heart monitor. They will take
attention and working memory tests on a computer and answer questions about how they
feel. They will eat a meal at the end of the test day.
- Some studies in adults have found that insulin and glucose blood levels are lower when a
long period of sitting is broken up with walking, compared to sitting without breaks. This
means that the body can better process sugars when there are walking breaks during the day.
Researchers want to know if this is also true for children. Some studies have found that
children s attention and memory might be better after exercise. Researchers want to know if
short walking breaks have the same effects.
Objectives:
- To understand if breaking up sitting with walking helps children s bodies better use sugars
and improves children s concentration.
Eligibility:
- Healthy children ages 7 to 11.
Design:
- Participants will be screened with a physical exam, medical history, exercise test,
picture vocabulary test, and medical tests including blood tests and X-rays.
- Participants will return for two 7-hour visits. In the month before the visits, they
will wear a physical activity monitor for one week so researchers know how active they
are. Once they will take the sitting only test and once the sitting breaks test.
- During the sitting only test, participants will sit for 3 hours.
- During the sitting breaks test, they will sit for 3 hours with 3-minute walking breaks
every 30 minutes.
- Both days, they will drink sugar water. Then the participants will have blood drawn from
a needle that is kept in place, and they will wear a heart monitor. They will take
attention and working memory tests on a computer and answer questions about how they
feel. They will eat a meal at the end of the test day.
Prevention of pediatric obesity and its complications are U.S. public health priorities.
Promoting physical activity has been proposed as an intervention strategy. Apart from
reducing excessive weight, physical activity improves cardiovascular fitness, insulin
sensitivity, and academic performance. However, emerging evidence in adults suggests that
increased physical activity may not entirely counteract the negative health effects of a
sedentary lifestyle.
Sedentary behavior is defined as a set of low-intensity activities involving limited body
movement (e.g.: TV viewing, prolonged sitting). TV viewing is associated with lower cognitive
functioning and depressive symptoms. Some studies found higher levels of childhood sedentary
behavior predicted higher body mass index (BMI) and cholesterol in adulthood, suggesting that
negative health consequences may begin early. Dunstan et al. conducted the first lab-based
study in adults investigating interrupting prolonged sedentary behavior with physical
activity breaks. The authors found that for overweight adults, adding 2-minute
moderate-intensity walking breaks every 20 minutes reduced postprandial insulin and glucose
responses by 23.0% and 29.6%, respectively. Thus, interrupting sedentary behavior may be an
intervention strategy to reduce health risks.
In children, cross-sectional observational studies indicate that sedentary behavior patterns
characterized by short bouts of activity are not associated with increased cardiometabolic
risk. However to date, no in-lab studies have manipulated sedentary behavior in children.
Therefore, we propose to conduct a randomized crossover pilot feasibility study to assess
whether interrupting sedentary behavior influences metabolic and executive function,
attention, mood, anxiety, and dietary intake. Children, ages 7-11 years, will complete two
conditions in random order: 3 hours of prolonged sitting and 3 hours of sitting interrupted
with 3 minutes of moderate-intensity walking every 30 minutes. The specific aim of this
project is to investigate whether interrupting sedentary behavior improves metabolic
parameters and changes executive function, attention, mood, anxiety, and dietary intake. The
primary hypothesis is that postprandial insulin incremental area under the curve (iAUC) will
be lower in the interrupted sitting vs. the prolonged sitting condition. The exploratory
secondary hypotheses are that glucose iAUC, executive function, attention, mood, anxiety, and
dietary intake will differ between the two conditions.
This project will investigate if interrupting sedentary time affects potential negative
health consequences of sedentary behavior in children. If interrupting sedentary time in
short bouts has beneficial effects among children, interventions examining the frequency,
duration, and intensity of such interruptions could be developed. Thus, these results have
the potential to provide insight into novel behavioral intervention targets in youth.
Promoting physical activity has been proposed as an intervention strategy. Apart from
reducing excessive weight, physical activity improves cardiovascular fitness, insulin
sensitivity, and academic performance. However, emerging evidence in adults suggests that
increased physical activity may not entirely counteract the negative health effects of a
sedentary lifestyle.
Sedentary behavior is defined as a set of low-intensity activities involving limited body
movement (e.g.: TV viewing, prolonged sitting). TV viewing is associated with lower cognitive
functioning and depressive symptoms. Some studies found higher levels of childhood sedentary
behavior predicted higher body mass index (BMI) and cholesterol in adulthood, suggesting that
negative health consequences may begin early. Dunstan et al. conducted the first lab-based
study in adults investigating interrupting prolonged sedentary behavior with physical
activity breaks. The authors found that for overweight adults, adding 2-minute
moderate-intensity walking breaks every 20 minutes reduced postprandial insulin and glucose
responses by 23.0% and 29.6%, respectively. Thus, interrupting sedentary behavior may be an
intervention strategy to reduce health risks.
In children, cross-sectional observational studies indicate that sedentary behavior patterns
characterized by short bouts of activity are not associated with increased cardiometabolic
risk. However to date, no in-lab studies have manipulated sedentary behavior in children.
Therefore, we propose to conduct a randomized crossover pilot feasibility study to assess
whether interrupting sedentary behavior influences metabolic and executive function,
attention, mood, anxiety, and dietary intake. Children, ages 7-11 years, will complete two
conditions in random order: 3 hours of prolonged sitting and 3 hours of sitting interrupted
with 3 minutes of moderate-intensity walking every 30 minutes. The specific aim of this
project is to investigate whether interrupting sedentary behavior improves metabolic
parameters and changes executive function, attention, mood, anxiety, and dietary intake. The
primary hypothesis is that postprandial insulin incremental area under the curve (iAUC) will
be lower in the interrupted sitting vs. the prolonged sitting condition. The exploratory
secondary hypotheses are that glucose iAUC, executive function, attention, mood, anxiety, and
dietary intake will differ between the two conditions.
This project will investigate if interrupting sedentary time affects potential negative
health consequences of sedentary behavior in children. If interrupting sedentary time in
short bouts has beneficial effects among children, interventions examining the frequency,
duration, and intensity of such interruptions could be developed. Thus, these results have
the potential to provide insight into novel behavioral intervention targets in youth.
- INCLUSION CRITERIA:
Participants will qualify for the study if they meet the following criteria:
1. Good general health.
2. Age greater than or equal to 7 and <11.99 years.
3. Fasting plasma glucose < 100 mg/dL
4. a) Phase 1: Body mass index (BMI) between the 5th and 85th percentiles, as determined
by the CDC age- and sex- specific growth charts.
b) Phase 2: BMI above the 85th percentile, as determined by the CDC age- and sex-
specific growth charts.
EXCLUSION CRITERIA:
1. Significant cardiac or pulmonary disease likely to or resulting in hypoxia or
decreased perfusion.
2. Evidence of impaired glucose tolerance or type 2 diabetes, including fasting plasma
glucose greater than or equal to 100 mg/dL.
3. Presence of other endocrinologic disorders leading to obesity (e.g.: Cushing
Syndrome).
4. Participants who have, or whose parent/guardians have, current substance abuse or a
psychiatric disorder or other condition that, in the opinion of the investigators,
would impede competence, compliance, or prevent the completion of the study.
5. Participants who have, or are currently receiving, anti-psychotic drugs that would
affect metabolism, cognitive outcomes, and body habitus.
6. Participants receiving medical treatment other than diet for hypertension or
dyslipidemia.
7. Participants with precocious puberty and/or receiving androgen and estrogen therapy.
8. Participants currently taking medications for ADHD, or any disorder or use of
medications known to affect body composition or weight.
9. Presence of pre-existing neurocognitive disabilities, or an age-adjusted score below
85 on the Picture Vocabulary Test at the screening visit.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
Phone: 800-411-1222
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