Longitudinal Study of Traumatic Brain Injury (TBI) in (University of Florida) UF Athletes
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Hospital, Neurology |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 30 |
| Updated: | 5/18/2017 |
| Start Date: | July 2013 |
| End Date: | July 2020 |
Diffusion Tensor Imaging (DTI) Compared to Serum Biomarkers and Standard Clinical Measures of Concussion in Female and Male Collegiate Athletes: a Longitudinal Survey Across the College Years.
To identify the changes in the brain following repeated sports-related concussion in men's
football, women's soccer, and women's lacrosse college athletes by reviewing the findings of
MRI studies that look at the structure of the brain and the appearance of the white matter
at baseline, during the acute phase of a concussive injury, and upon completion of
collegiate athletic play and correlate these findings with standard clinical measures.
football, women's soccer, and women's lacrosse college athletes by reviewing the findings of
MRI studies that look at the structure of the brain and the appearance of the white matter
at baseline, during the acute phase of a concussive injury, and upon completion of
collegiate athletic play and correlate these findings with standard clinical measures.
This proposal seeks to study Diffusion Tensor Imaging and functional MRI of the brain at 1)
baseline, 2) after concussion and 3) at the end of an athlete's college career. Findings
will be compared to standard clinical measures already performed in the management of
concussion at the University of Florida Athletic Association and to serum biomarkers already
being obtained as part of a UF/ Banyan Biomarker Study. As in the biomarker study, UF
athletes on teams with higher incidences of sports related concussion; men's football,
women's soccer, and women's lacrosse will be offered enrollment.
Longitudinal examinations will allow identification and quantification of concussive DTI
findings as comparisons can be made to the individual athlete's baseline data. This will
provide valuable correlation of imaging findings with severity of clinical symptoms at the
time of injury and also with timing of return to play.
baseline, 2) after concussion and 3) at the end of an athlete's college career. Findings
will be compared to standard clinical measures already performed in the management of
concussion at the University of Florida Athletic Association and to serum biomarkers already
being obtained as part of a UF/ Banyan Biomarker Study. As in the biomarker study, UF
athletes on teams with higher incidences of sports related concussion; men's football,
women's soccer, and women's lacrosse will be offered enrollment.
Longitudinal examinations will allow identification and quantification of concussive DTI
findings as comparisons can be made to the individual athlete's baseline data. This will
provide valuable correlation of imaging findings with severity of clinical symptoms at the
time of injury and also with timing of return to play.
Inclusion Criteria:
- Currently enrolled and active UF student athlete in Mens Football, Womens Soccer, or
Womens Lacrosse.
- Age 18-30
Exclusion Criteria:
- Contraindications to MRI, such as retained metal
- Pregnancy
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