Bioenergetics in Surgical Patients
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 19 - 80 |
| Updated: | 8/19/2018 |
| Start Date: | December 2012 |
| End Date: | December 2019 |
| Contact: | William O. Richards, MD |
| Email: | brichards@usouthal.edu |
| Phone: | 251-471-7993 |
To identify patients who may be predisposed for developing MOF (multiple organ failure)by the
sampling of blood.
sampling of blood.
The rationale for doing this study is the recognition that mitochondrial DNA Damage
Associated Molecular Patterns (mtDAMPs) accumulate in the circulation after severe injury.
Furthermore our own studies in severely injured patients identify that the mtDAMPS are
increased 3-28 fold in those patients who eventually develop multiple organ dysfunction
syndrome (MODS) compared to those severely traumatized patients who did not develop MODS. The
relative risk of death from MODS after severe trauma was increased 8-20 times in those
patients with elevated mt DAMP levels.
This study is then being done to correlate mitochondrial damp levels in surgical trauma to
assess the time course and the levels of mtDAMPs with the type of surgical procedure. We
believe that this information will help us to determine the time course of events and the
triggers for development of multiple organ dysfunction seen after surgery.
Associated Molecular Patterns (mtDAMPs) accumulate in the circulation after severe injury.
Furthermore our own studies in severely injured patients identify that the mtDAMPS are
increased 3-28 fold in those patients who eventually develop multiple organ dysfunction
syndrome (MODS) compared to those severely traumatized patients who did not develop MODS. The
relative risk of death from MODS after severe trauma was increased 8-20 times in those
patients with elevated mt DAMP levels.
This study is then being done to correlate mitochondrial damp levels in surgical trauma to
assess the time course and the levels of mtDAMPs with the type of surgical procedure. We
believe that this information will help us to determine the time course of events and the
triggers for development of multiple organ dysfunction seen after surgery.
Inclusion Criteria:
- Patients @ USAMC undergoing surgical operations expected to have microcirculatory
changes, i.e., CABG, open heart, aortic or other revascularizing operations, general
surgical operations such as colon resections, bowel resections or any other surgical
procedures in which the subject could be expected to or might develop multiple system
organ failure.
Exclusion Criteria:
We found this trial at
1
site
Mobile, Alabama 36604
Principal Investigator: William O. Richards, MD
Phone: 251-471-7993
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