Bioavailability Study of SPD489 Administered With Two Different Means of Administration in Healthy Adult Volunteers

Inclusion Criteria:

1. Age 18-55 years inclusive at the time of consent. The date of signing informed consent
is defined as the beginning of the Screening Period. This inclusion criterion will
only be assessed at the first screening visit.

2. Willingness to comply with any applicable contraceptive requirements fo the protocol
and is:

- Male, or

- Non pregnant, non lactating female

- Females must be at least 90 days post partum or nulliparous

3. Must be considered "healthy". Healthy status is defined by absence of evidence of any
active or chronic disease following a detailed medical and surgical history, a
complete physical examination including vital signs, 12-lead electrocardiogram,
hematology, blood chemistry, and urinalysis.

4. An understanding, ability, and willingness to fully comply with study procedures and
restrictions

5. Ability to provide written, personally signed, and dated informed consent to
participate in the study, in accordance with International Conference on harmonisation
Good Clinical Practice Guideline E6 (1996) and applicable regulations, before
completing any study related procedures

6. A body mass index between 18.5-30.0kg/m² inclusive. This inclusion criterion will only
be assessed at the first screening visit.

7. A hemoglobin value of >=12.0g/dL at the Screening Visit and on Day -1 of Treatment
Period 1.

8. Ability to swallow a dose of investigational product according to the study
conditions.

Exclusion Criteria:

Subjects are excluded from the study if any of the following criteria are met at the
Screening Visit or at Day 1 of Treatment Period 1 (if reassessed):

1. Current or recurrent disease (eg, cardiovascular, renal, liver, gastrointestinal,
malignancy, or other conditions) that could affect the action, absorption, or
disposition of the investigational products, or could affect clinical or laboratory
assessments.

2. Current or relevant history of physical or psychiatric illness, any medical disorder
that may require treatment or make the subject unlikely to fully comply with the
requirements of the study or complete the study, or any condition that presents undue
risk from the investigational product or study procedures.

3. Significant illness, as judged by the investigator, within 2 weeks of the first dose
of investigational product.

4. History of significant anxiety, tension, or agitation as assessed by the investigator.

5. History of or current diagnosis of glaucoma.

6. History of a seizure disorder (other than infantile febrile seizures), any tic
disorder, or a current diagnosis and/or known family history of Tourette's Disorder.

7. History or presence of known structural cardiac abnormalities, syncope, cardiac
conduction problems, exercise-related cardiac events, or clinically significant
bradycardia.

8. History of symptomatic cardiovascular disease, advanced arteriosclerosis, structural
cardiac abnormality, cardiomyopathy, serious heart rhythm abnormalities, coronary
artery disease, transient ischemic attack or stroke or other serious cardiac problems
that may place them at increased vulnerability to the sympathomimetic effects of a
stimulant drug.

9. History of controlled or uncontrolled hypertension or a resting supine systolic blood
pressure >139mmHg or diastolic blood pressure >89mmHg.

10. Known family history of sudden cardiac death or ventricular arrhythmia.

11. Currently considered a suicide risk, has previously made a suicide attempt, or has a
history of, or is currently demonstrating suicidal ideation.

12. Current use of any medication (including prescription, over-the-counter, herbal or
homeopathic preparations) with the exception of hormonal replacement therapy or
hormonal contraceptives (current use is defined as use within 14 days of first dose of
investigational product).

13. Use of any medication known to inhibit or induce the cytochrome P450 (CYP450) enzymes
responsible for the metabolism of the investigational product within 14 days of first
dose of investigational product.

14. Known or suspected intolerance or hypersensitivity to the investigational product,
closely related compounds, or any of the stated ingredients.

15. Known or suspected intolerance or hypersensitivity to orange juice or vanilla yogurt.

16. History of alcohol or other substance abuse within the last year.

17. A positive screen for alcohol or drugs of abuse at the Screening Visit or on Day 1 of
Treatment Period 1.

18. Male subjects who consume more than 3 units of alcohol per day. Female subjects who
consume more than 2 units of alcohol per day. (1 alcohol unit=1 beer=1 wine [5oz]=one
liquor [1.5 oz]=0.75oz alcohol.).

19. A positive human immunodeficiency virus antibody screen, Hepatitis B surface antigen,
or Hepatitis C virus antibody screen.

20. Use of tobacco in any form (eg, smoking or chewing) or other nicotine-containing
products in any form (eg, gum, patch) within 30 days prior to the first dose of
investigational product.

21. Routine consumption of more than 2 units of caffeine per day or subjects who
experience caffeine withdrawal headaches or have a history of caffeine withdrawal
headaches. (One caffeine unit is contained in the following items: one 6oz cup of
coffee, two 12oz cans of cola, one 12oz cup of tea, three 1oz chocolate bars.
Decaffeinated coffee, tea, or cola are not considered to contain caffeine).

22. Donation of blood or blood products (eg, plasma or platelets) within 60 days prior to
the first dose of investigational product.

23. Use of another investigational product within 30 days prior to receiving the first
dose of investigational product or active enrollment in another drug or vaccine
clinical study.

24. Substantial changes in eating habits within 30 days prior to receiving the first dose
of investigational product, as assessed by the investigator.

25. An inability to follow a standardized diet and meal schedule or inability to fast, as
required during the study.

26. Prior screen failure, randomization, participation, or enrollment in this study