Effect of TU-100 in Patients With Irritable Bowel Syndrome (IBS)

Inclusion Criteria:

1. Meet Rome III criteria for IBS.

2. Willing and able to provide written informed consent.

3. If a female of childbearing potential, must be using an acceptable form of
contraception during the study and for 30 days after the last dose. Acceptable
methods include surgical sterilization, hormonal contraceptives (such as oral
contraceptives, Depo-Provera, NuvaRing), condoms used with a spermicide, an IUD
[Intrauterine device] or abstinence.

Females are not considered to be of childbearing potential if they are postmenopausal
for at least 2 years or have been surgically sterilized.

4. Aged 18 to 65 years, inclusive.

5. Have a body mass index (BMI) between 18 and 40 kg/m2, inclusive.

6. Have a negative urine drug screening at Visit 1.

7. Have normal or not clinically significant laboratory results as reviewed by the study
physicians.

8. Have a normal rectal examination result on file within the past 2 years or performed
at Visit 1 in order to exclude the possibility of an evacuation disorder (examination
must exclude findings suggestive of an evacuation disorder such as high sphincter
tone at rest, failure of perineal descent and spasm, tenderness or paradoxical
contraction of the puborectalis muscles).

9. Agree to avoid alcohol during the entire study to avoid corrupting the data from the
rectal barostat tests.

Exclusion Criteria:

1. Have a structural or metabolic diseases or conditions that affect the GI system.

2. Be taking any medication that in the opinion of the principal investigator has a
potential to alter GI transit (this includes but is not limited to osmotic or
stimulant laxatives, magnesium or aluminum-containing antacids, prokinetics,
erythromycin, gabapentin, pregabalin, narcotics, anticholinergics, antidepressants
[including selective norepinephrine reuptake inhibitors], antipsychotics, opiates,
GABAergic agents and benzodiazepines).

Note: Tricyclic antidepressants are permissible at doses equal to or less than 25 mg
daily; selective serotonin reuptake inhibitor antidepressants are permissible at low,
stable doses. Analgesics such as Tylenol, ibuprofen, naproxen and aspirin are not
permissible during Visits 2 and 3 to avoid corrupting data from the rectal barostat
tests. All medications will be reviewed by the principal investigator on a case by
case basis.

Rescue medications: Rescue medications will be reviewed and approved as necessary for
exacerbation of constipation or diarrhea since the study medication treatment period
is about 14 days total. The patient will contact the study staff to request review
and approval of the use of a rescue medication by the principal investigator. The use
of the rescue medication will be documented by the patient in the bowel pattern,
bloating and pain diary. Rescue medications are not allowed within 7 days of the
rectal sensation studies to ensure data integrity.

3. Have clinical evidence, including but not limited to, of a clinically significant
abnormal physical examination or laboratory value or of a past event documented in
the past medical record, or current clinically significant abnormal physical
examination or laboratory value that could indicate significant cardiovascular,
respiratory, renal, hepatic, GI, hematological, neurological, psychiatric or other
diseases that interfere with the objectives of the study. If a laboratory test value
falls outside of the reference range and is considered clinically significant, it may
be repeated once at the discretion of the principal investigator. If the laboratory
test result remains abnormal and clinically significant, the patient will be
discontinued from the study and referred to a primary care physician for evaluation.

4. Be a known substance abuser or be considered to be an alcoholic not in remission.

5. Have participated in another clinical study in the past 30 days.

6. Have a history of allergic reactions to egg, ginseng, ginger or Sichuan pepper.

7. Be clinically lactose intolerant.