A Study of LY3015014 in Participants With High Cholesterol

Inclusion Criteria:

- Diagnosed with high low density lipoprotein (LDL) cholesterol

- Are on stable daily dose of a statin or have a history of statin intolerance

- Men with a partner who can become pregnant must agree to use barrier protection
during sexual intercourse to prevent pregnancies

- Women who cannot become pregnant, or women who are not pregnant or breast feeding and
agree to use a reliable method of birth control to prevent pregnancies

Exclusion Criteria:

- Have high cholesterol due to another disease or have a rare and serious form of
hereditary high cholesterol

- Have had recent heart attack, stroke, blood clot or heart surgery, have planned
heart or blood vessel surgery, or has a heart that does not pump sufficiently well

- Have poorly controlled high blood pressure

- Have diabetes that requires an injectable medication (including insulin), or have
diabetes that is poorly controlled

- Have thyroid blood test that is outside normal range

- Have a history of adrenal gland disorder

- Have a history of vitamin E deficiency or fat malabsorption syndrome

- Have poor kidney function

- Have active liver or gall bladder disease, history of hepatitis or liver blood tests
that are high

- Have a history of muscle disease including muscle damage from a medicine or muscle
blood test that is high

- Are anemic (low red blood cell counts)

- Have a history of allergy or intolerance to other antibody medications

- Have a history of human immunodeficiency virus infection (HIV) infection

- Are likely to have a major operation or be hospitalized during the study

- Have chronic alcohol or drug abuse or dependency

- Have or suspected to have any cancer or malignant tumor

- Have an active serious infection

- Have started or stopped taking a statin or ezetimibe medication, or changed statin
dose regimen recently

- Are on a statin regimen other than daily dosing (for example, an every-other-day
statin regimen)

- Have recently used simvastatin (highest dose level), fibrates, bile acid binders,
niacin, probucol, or over-the-counter/health food preparations to lower cholesterol
(such as red yeast rice, fish oil, omega 3 fatty acid)

- Have undergone LDL apheresis in the past 1 year

- Have recently used steroids, cyclosporine or isotretinoin

- Have recently used an immunosuppressive therapy

- Have recently received treatment with another antibody medication

- Are currently using medications injected into the skin , except for single injections
(for example flu vaccines) or injections into muscles

- Are currently on a prescription or over-the-counter medicine for weight loss or are
on a very low carbohydrate diet