Clinical Characteristics of Dementias That Occur Remotely After Traumatic Brain Injury in Retired Military Personnel
| Status: | Withdrawn |
|---|---|
| Conditions: | Cognitive Studies, Infectious Disease, Hospital, Neurology, Psychiatric |
| Therapuetic Areas: | Immunology / Infectious Diseases, Neurology, Psychiatry / Psychology, Other |
| Healthy: | No |
| Age Range: | 50 - 95 |
| Updated: | 1/20/2019 |
| Start Date: | July 2013 |
| End Date: | August 2016 |
Endophenotypes of Dementia Associated With Traumatic Brain Injury in Retired Military Personnel
The objective of this study is to measure the frequency and clinical types of mild cognitive
impairment (MCI) or dementia that occur among up to 150 military retirees with and without a
history of traumatic brain injury (TBI) among residents of the Armed Forces Retirement Home,
Washington D.C. and the Veterans Home of California-Yountville. Investigators will compare
the characteristics of dementia in those who have had a prior TBI to the characteristics in
those without a history of TBI. It is our hypothesis that the dementia or MCI among those
with prior TBI has distinct neuropsychological features that distinguishes it from those with
dementia or MCI without a history of TBI.
impairment (MCI) or dementia that occur among up to 150 military retirees with and without a
history of traumatic brain injury (TBI) among residents of the Armed Forces Retirement Home,
Washington D.C. and the Veterans Home of California-Yountville. Investigators will compare
the characteristics of dementia in those who have had a prior TBI to the characteristics in
those without a history of TBI. It is our hypothesis that the dementia or MCI among those
with prior TBI has distinct neuropsychological features that distinguishes it from those with
dementia or MCI without a history of TBI.
75 participants with a history of TBI will be the cases (exposed) group. A control group of
75 retirement home residents without a history of TBI who are age-matched to the cases will
also be recruited. Participants will be evaluated in a single visit, which will include
neurological, psychiatric, and cognitive assessment. The evaluation will take approximately 4
hours. In some cases, the evaluation may be split into two 2 hour sessions.
75 retirement home residents without a history of TBI who are age-matched to the cases will
also be recruited. Participants will be evaluated in a single visit, which will include
neurological, psychiatric, and cognitive assessment. The evaluation will take approximately 4
hours. In some cases, the evaluation may be split into two 2 hour sessions.
Inclusion Criteria:
Cases (with a history of TBI):
1. Ages 50-95 years
2. History of traumatic brain injury of sufficient severity to have resulted in medical
attention (ascertained via the Ohio State University TBI Identification
Questionnaire—OSU TBI-ID, and based on DoD/VA criteria)
3. Residence in AFRH-Washington D.C. or the Veterans Home of California-Yountville
4. MMSE score ≥ 20
5. Capacity to provide consent to participate in research (assessment made by study
physician)
6. Ability to read and write English
Controls (without a history of TBI):
1. Ages 50-95 years
2. No history of traumatic brain injury of sufficient severity to have resulted in
medical attention (ascertained via the Ohio State University TBI Identification
Questionnaire—OSU TBI-ID)
3. Residence in AFRH-Washington or the Veterans Home of California-Yountville
4. MMSE score ≥ 20
5. Capacity to provide consent or assent to participate in research
6. Ability to read and write English -
Exclusion Criteria:
Cases (with a history of TBI):
1. History of penetrating brain injury
2. History of disabling neurological or psychiatric condition such as epilepsy (besides
posttraumatic epilepsy), multiple sclerosis, cortical stroke, hypoxic-ischemic
encephalopathy, encephalitis, or schizophrenia
Controls (without a history of TBI):
History of disabling neurological or psychiatric condition such as epilepsy, multiple
sclerosis, cortical stroke, hypoxic-ischemic encephalopathy, encephalitis, or schizophrenia
We found this trial at
2
sites
Yountville, California 94599
Principal Investigator: Kristine Yaffe, MD
Phone: 415-221-4810
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