Ketamine for Acute Suicidal Ideation in the Emergency Department: Randomized Controlled Trial
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Hospital, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology, Other |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 4/2/2016 |
| Start Date: | June 2015 |
| Contact: | Steven G Schauer, DO |
| Email: | sgschauer@gmail.com |
| Phone: | 2109160808 |
This study will enroll patients presenting to the emergency department with acute suicidal
ideation meeting inclusion and exclusion criteria. Patients will be randomized to one of
three arms: ketamine (intervention) or diphenhydramine (control) or placebo (control).
Serial measurements will be made in the ED and at follow-up intervals.
ideation meeting inclusion and exclusion criteria. Patients will be randomized to one of
three arms: ketamine (intervention) or diphenhydramine (control) or placebo (control).
Serial measurements will be made in the ED and at follow-up intervals.
Inclusion Criteria:
- Patients age 18 to less than 75 who present to the SAMMC ED with either overt or
incidental suicidal ideations with a SADPERSONS score 5 or greater that the treating
provider feels warrant formal evaluation.
Exclusion Criteria:
- -Poor vital sign stability hypoxia: O2 < 95%, hypotension: SBP< 90 hypertension:
SBP>180 Heart rate: < 50 or >120 Respiratory Rate: <10 or >30
- Altered mental status or intoxication
- Patient is unwilling to participate or provide informed consent
- Any allergy to ketamine or diphenhydramine
- Patient is female of child-bearing age and unwilling to provide urine or blood for
HCG analysis
- Pregnancy or breast feeding
- Presence of chronic oxygen-dependent pulmonary disease, liver cirrhosis, or renal
disease requiring dialysis
- Presence of ischemic heart disease, heart failure, or a history of unstable
dysrhythmias
- Presence of intracranial mass or vascular lesion.
- Presence of a history of psychosis or hallucinations (as assessed by electronic chart
review)
- Weight greater than 115 kg or less than 45kg
- History of increased intracranial pressure/hypertensive hydrocephalus
- Non-English speaking patients
- Patient is acutely psychotic
- Provider feels that patient currently or likely will require chemical and/or physical
restraints
- History of prolonged QT-interval
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