Comparison of Time-Restricted Feeding Versus Grazing

Each participant will eat according to one of the two eating schedules (grazing or
time-restricted feeding) for 5 weeks, have a 7-week washout period, and then eat according to
the other eating schedule for 5 weeks. Measurements of glucose homeostasis and vascular
condition will be performed before and after a participant follows each eating schedule.

Inclusion Criteria:

- Are male

- Overweight: Have a body mass index between 25 and 50 kg/m^2 inclusive (a number
calculated from height and weight)

- Are 35-70 years of age

- Have a hemoglobin A1C between 5.5 - 6.4% or prior medical indication of prediabetes

- Have a blood sugar level between 140 and 199 mg/dL two hours after drinking a sugary
solution (OGTT)

- Have been eating dinner at least 8.5 hours after eating breakfast at least 90% of the
time during the past year

- Have not fasted (go for a day without any food) more than 12 days total during the
past year

- Be willing to eat most meals at Pennington Biomedical and/or under supervision

- Not eat any food other than that served by Pennington Biomedical

- Not drink any alcohol, juice, or other beverages that have calories other than what is
served by Pennington Biomedical

- Keep water and no-calorie drinks like tea or diet soda the same during both of the
timed eating periods

- Be willing to eat your meals according to the fixed schedules

Exclusion Criteria:

- Have diabetes or are on anti-diabetes medication

- Have evidence of cardiovascular disease

- Suffer from significant cardiovascular, renal (kidney), cardiac (heart), liver, lung
or nervous system disease

- Evidence of significant gastrointestinal issues or surgery that impacts nutrient
absorption

- Regularly use medications such as steroids, beta blockers, and adrenergic-stimulating
agents

- Are on any regular medicine that has not had the same dose for 1 month or longer

- Have a clinically significant abnormality as measured by a blood test

- Regularly drink alcohol (more than 2 servings per day)

- Have to do any kind of heavy physical activity

- Currently perform overnight shift work more than one day a week

- Are not able to eat only the food served to you by Pennington Biomedical, while in the
study

- Are not able to stop drinking alcohol or other drinks with calories (e.g., soda,
juice) other than what is served to you by Pennington Biomedical, while in the study