Pradaxa Study in Non-valvular Atrial Fibrillation Patients With Severely Impaired Renal Function

Inclusion criteria:

- Subjects diagnosed with non-valvular atrial fibrillation with an indication for the
anticoagulation therapy,

- Subjects with severe renal function impairment defined as creatinine clearance
between 15 and 30 mL/min by Cockcroft-Gault formula,

- Male and female patients, age =18 years at entry

Exclusion criteria:

- Contraindications to Pradaxa (history of a serious hypersensitivity reaction to
Pradaxa, active pathological bleeding, patients with mechanical prosthetic heart
valve),

- Creatinine clearance <15ml/min or patients with End Stage Renal Disease on dialysis,

- Creatinine clearance >30 ml/min,

- Pre-menopausal women (last menstruation less than one year prior to informed consent)
who are nursing or pregnant, or are of child bearing potential and are not practicing
an acceptable method of birth control, or do not plan to continue using this method
throughout the study. Acceptable methods of birth control include abstinence, tubal
ligation, transdermal patch, intra uterine devices/systems (IUDs/IUSs), oral,
implantable or injectable contraceptives, double barrier method and vasectomised
partner,

- Patients who are participating in another drug study,

- Patients who have participated in another drug study within 6 weeks,

- Patients considered unreliable by the investigator concerning the requirements for
participating in the study, including a follow-up interview,

- Any condition the investigator believes would not allow safe participation in the
study,