Feasibility of Blood Oxygenation Level-Dependent Contrast (BOLD) Breast MRI Induced by Breath- Holding
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/3/2018 |
| Start Date: | September 2013 |
| End Date: | April 2014 |
A Pilot Study of the Feasibility of Blood Oxygenation Level-Dependent Contrast ( BOLD) Breast MRI Induced by Breath- Holding
In this study, investigators intend to measure changes in BOLD contrast in the breast induced
by breath-holding for subjects receiving radiation therapy to the breast. This study will
provide the preliminary data and experience needed to successfully apply BOLD to quantify
changes in oxygenation and blood flow of breast and tumor for a larger cohort of breast
radiotherapy patients. The current study has the following objectives:
1. To determine the feasibility of BOLD contrast MRI of the breast, induced by breath-hold.
2. To measure the change in BOLD contrast of the breast and / or chest wall tissue for
females undergoing radiotherapy
by breath-holding for subjects receiving radiation therapy to the breast. This study will
provide the preliminary data and experience needed to successfully apply BOLD to quantify
changes in oxygenation and blood flow of breast and tumor for a larger cohort of breast
radiotherapy patients. The current study has the following objectives:
1. To determine the feasibility of BOLD contrast MRI of the breast, induced by breath-hold.
2. To measure the change in BOLD contrast of the breast and / or chest wall tissue for
females undergoing radiotherapy
11 subjects were consented to the trial. One subject voluntarily withdrew before any study
procedures were performed.
procedures were performed.
Inclusion Criteria: • Post-operative patients who are undergoing planning for future whole
breast radiation therapy may be included in the study
- Female
- Age ≥18
- Negative serum pregnancy test for women of child bearing potential
- Signed study-specific informed consent
Exclusion Criteria:
- Unable to perform breath-holding of adequate duration.
- Unable to lie prone for approximately one hour during the study procedure
- Breast implants
- Any condition for which a MRI procedure is contraindicated including presence of
metallic material in the body, such as pacemakers, non- MRI compatible surgical clips,
shrapnel, etc.
- Positive serum pregnancy test
- Mastectomy
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