The Neural Correlates of Food Choice Decision-making in Obesity and Weight Loss
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 35 - 55 |
| Updated: | 4/2/2016 |
| Start Date: | March 2010 |
| End Date: | October 2016 |
| Contact: | Kathryn E Demos, PhD |
| Email: | kathryn_demos@brown.edu |
| Phone: | 401-793-8939 |
The Neural Correlates of Food Choice Decision-making in Obesity and Weight Loss (CHOICES)
This study is designed to determine whether obese, normal weight, and successful weight loss
maintainers differ in their food choice decision-making and/or executive function, and
whether participation in a behavioral weight loss program leads to neural and/or behavioral
changes. The investigators will examine behavioral performance on several tasks involving
decision-making and self-control in conjunction with brain imaging data acquired during a
food-choice decision-making task. Participants enrolled in the behavioral weight loss
program will also be assessed following the treatment.
maintainers differ in their food choice decision-making and/or executive function, and
whether participation in a behavioral weight loss program leads to neural and/or behavioral
changes. The investigators will examine behavioral performance on several tasks involving
decision-making and self-control in conjunction with brain imaging data acquired during a
food-choice decision-making task. Participants enrolled in the behavioral weight loss
program will also be assessed following the treatment.
Inclusion Criteria:
- women, ages 35-55, who are either currently obese (BMI = 30-40 kg/m2), always normal
weight (lifetime BMI < 25, NW) or successful weight loss maintainers who have lost
10% of their body weight and maintained that loss for at least 1 year (lifetime
maximum BMI = 30-40 kg/m2)
Exclusion Criteria:
- weight loss medications, binge eating, standard MRI contraindications (e.g., metal
implants, claustrophobia, pregnancy), left-handedness, food allergies, neurological
or psychiatric conditions, including but not limited to schizophrenia, bipolar
disorder, epilepsy, stroke and traumatic brain injury with loss of consciousness,
and, among obese participants, inability to participate at two time points and lack
of interest in participating in a behavioral weight loss trial
- serious current physical disease (e.g., heart disease and cancer) for which physician
supervision of diet and exercise prescription is needed, physical problems that limit
the ability to exercise, participation in a weight loss program in the last 2 months
and intention to become pregnant in the next 6 months
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2
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