Tofacitinib In Psoriatic Arthritis Subjects With Inadequate Response to TNF Inhibitors



Status:Completed
Conditions:Arthritis, Psoriasis
Therapuetic Areas:Dermatology / Plastic Surgery, Rheumatology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:August 2013
End Date:April 2016

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 3, Randomized, Double-blind, Placebo-controlled Study Of The Efficacy And Safety Of 2 Doses Of Tofacitinib (Cp-690,550) In Subjects With Active Psoriatic Arthritis And An Inadequate Response To At Least One Tnf Inhibitor

To examine the safety and efficacy of tofacitinib in subjects with active psoriatic
arthritis who have previously had an inadequate response to at least one TNF inhibitor
either due to lack of efficacy or an adverse event.


Inclusion Criteria:

- Active arthritis at screening/baseline as indicated by >/= 3 tender/painful and 3
swollen joints

- Active plaque psoriasis at screening

- Inadequate efficacy or lack of toleration to previously administered TNF inhibitor

Exclusion Criteria:

- Non-plaque forms of psoriasis (with exception of nail psoriasis)

- History of autoimmune rheumatic disease other than PsA; also prior history of or
current, rheumatic inflammatory disease other than PsA
We found this trial at
41
sites
Drug Shipment/Storage: Investigational Drug Services
Salt Lake City, Utah 84112
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Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Boston, MA
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East Penn Rheumatology Associates, P.C.
Bethlehem, Pennsylvania 18015
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Bethlehem, PA
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Rheumatology Associates, PC
Birmingham, Alabama 35205
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Birmingham, AL
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St. Luke's Intermountain Research Center
Boise, Idaho 83702
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Boise, ID
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Royal Prince Alfred Hospital, Rheumatology Department
Camperdown, New South Wales 2050
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Camperdown,
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Low Country Rheumatology
Charleston, South Carolina 29406
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Charleston, SC
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Cincinnati Rheumatic Disease Study Group
Cincinnati, Ohio 45219
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Cincinnati, OH
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University Hospitals Case Medical Center - Department of Dermatology
Cleveland, Ohio 44106
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Cleveland, OH
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Adriana Pop-Moody MD - Clinic PA
Corpus Christi, Texas 78404
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Corpus Christi, TX
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Medvin Clinical Research
Covina, California 91723
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Covina, CA
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Metroplex Clinical Research Center
Dallas, Texas 75231
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Dallas, TX
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Altoona Center for Clinical Research
Duncansville, Pennsylvania 16635
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Duncansville, PA
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St. Paul Rheumatology, PA
Eagan, Minnesota 55121
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Eagan, MN
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St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare
Fullerton, California 92835
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Fullerton, CA
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Arizona Arthritis & Rheumatology Associates, PC
Glendale, Arizona 85304
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Glendale, AZ
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Klein & Associates MD, PA.
Hagerstown, Maryland 21740
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Hagerstown, MD
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Pioneer Research Solutions, Inc.
Houston, Texas 77098
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Houston, TX
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Rheumatology Associates Of North Alabama, P.C.
Huntsville, Alabama 35801
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Huntsville, AL
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Covance Central Laboratory Service
Indianapolis, Indiana 46214
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Indianapolis, IN
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The Arthritis Clinic
Jackson, Tennessee 38305
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Jackson, TN
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West Tennessee Research Institute
Jackson, Tennessee 38305
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Jackson, TN
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Dartmouth-Hitchcock Medical Center (DHMC)
Lebanon, New Hampshire 03756
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Lebanon, NH
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Bluegrass Community Research, Inc
Lexington, Kentucky 40504
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Lexington, KY
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Physician Research Collaboration
Lincoln, Nebraska 68512
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Lincoln, NE
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Ronald Reagan UCLA Medical Center - Drug Information Center
Los Angeles, California 90095
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Los Angeles, CA
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Paramount Medical Research & Consulting, Llc
Middleburg Heights, Ohio 44130
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Middleburg Heights, OH
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Rheumatology Associates of Central Florida
Orlando, Florida 32806
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Orlando, FL
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Millennium Research
Ormond Beach, Florida 32174
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Ormond Beach, FL
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The Arthritis Center
Palm Harbor, Florida 34684
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Palm Harbor, FL
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Integral Rheumatology & Immunology Specialists (IRIS)
Plantation, Florida 33324
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Plantation, FL
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University of Utah Hospital and Clinics
Salt Lake City, Utah 84132
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Salt Lake City, UT
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San Diego Arthritis Medical Clinic
San Diego, California 92108
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San Diego, CA
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Seattle Rheumatology Associates
Seattle, Washington 98104
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Seattle, WA
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Clayton Medical Research
St. Louis, Missouri 63117
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St. Louis, MO
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Stanford Hospital and Clinics
Stanford, California 94305
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Stanford, CA
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New England Research Associates, Llc
Trumbull, Connecticut 06611
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Trumbull, CT
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The Center for Rheumatology and Bone Research
Wheaton, Maryland 20902
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Wheaton, MD
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Clinical Pharmacology Study Group
Worcester, Massachusetts 01610
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Worcester, MA
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Florida Medical Clinic
Zephyrhills, Florida 33542
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Zephyrhills, FL
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