Walnut Consumption, Endothelial Function, and Biomarkers
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology, Cardiology, Diabetes, Diabetes |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology |
| Healthy: | No |
| Age Range: | 30 - Any |
| Updated: | 4/21/2016 |
| Start Date: | June 2013 |
| End Date: | September 2015 |
Walnut Consumption, Endothelial Function, and Plasma Adipokines in Subjects With Diabetes or Coronary Disease: a Pilot Trial
This study will examine whether a twelve-week intervention with one ounce (28 g) per day of
walnuts improves endothelial function measured non-invasively using finger probe
(EndoPat-2000) in people with coronary heart disease or type 2 diabetes.
walnuts improves endothelial function measured non-invasively using finger probe
(EndoPat-2000) in people with coronary heart disease or type 2 diabetes.
Inclusion Criteria:
- Age 30+ years
- Prevalent coronary artery disease
- Prevalent type 2 diabetes
Exclusion Criteria:
- Current eating disorder
- Pregnant or lactating women
- Allergy to walnuts or other nuts
- Inability to provide informed consent or blood samples
- History or prevalent diagnosis of cancer, asthma, kidney insufficiency, stroke,
seizures, allergic disorders, or congestive heart failure
- Diagnosis of coronary heart disease or diabetes < 1 year prior to enrollment
- Intention to move out of greater Boston area within one year
- Current use of walnuts for more than 2 ounces per day
- Bleeding disorder
- Treatment with blood thinning drugs (i.e. warfarin, clopidogrel)
- Major surgical operation 3 months before or after screening
- Organ transplantation
- Current participation in another trial or plan to do so during the study
- Use of vasodilators such as nitroglycerin
- Inability to give informed consent
- Inability to travel to the study center at Brigham and Women's Hospital
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