Ketamine and Morphine Versus Morphine Alone for the Treatment of Acute Pain in the Emergency Department
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain, Hospital |
| Therapuetic Areas: | Musculoskeletal, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | June 2013 |
| End Date: | March 2015 |
| Contact: | Matthew Berkman, MD |
| Email: | mberkman@aemrc.arizona.edu |
| Phone: | (520) 626-5510 |
Our goal is to study whether giving people low dose ketamine along with morphine when they
come to the Emergency Department will help their pain more than giving morphine by itself.
There have been many studies showing that low dose ketamine is safe and effective for pain
control. Ketamine is frequently used for pain control in ambulances and helicopters
transporting injured patients to the hospital and has also been used for pain control in
people who have just had surgery. The investigators would like to see if low dose ketamine
would be safe and effective for patients with pain in the Emergency Department.
Patients are eligible for the study if they come to the Emergency Department and their
treating physician decides to treat them with morphine (with certain exceptions such as
pregnant patients and patients with eye injuries). They will be given information about
participating in the study and if they agree, they will be given the study drug. The study
drug will be either ketamine or salt water (saline). If patients continue to be in pain they
will continue to receive doses of morphine just as they would if they were not in the study.
If the treating physician feels that morphine alone is not enough, they will be free to
choose another pain medication as they would normally.
come to the Emergency Department will help their pain more than giving morphine by itself.
There have been many studies showing that low dose ketamine is safe and effective for pain
control. Ketamine is frequently used for pain control in ambulances and helicopters
transporting injured patients to the hospital and has also been used for pain control in
people who have just had surgery. The investigators would like to see if low dose ketamine
would be safe and effective for patients with pain in the Emergency Department.
Patients are eligible for the study if they come to the Emergency Department and their
treating physician decides to treat them with morphine (with certain exceptions such as
pregnant patients and patients with eye injuries). They will be given information about
participating in the study and if they agree, they will be given the study drug. The study
drug will be either ketamine or salt water (saline). If patients continue to be in pain they
will continue to receive doses of morphine just as they would if they were not in the study.
If the treating physician feels that morphine alone is not enough, they will be free to
choose another pain medication as they would normally.
Inclusion Criteria:
- Presenting to Emergency Department in acute pain
- age 18 and over
- determined to require morphine for pain control by treating physician
Exclusion Criteria:
- Patients presenting with headache or head injury
- Patient with eye injury or eye pain
- Nontraumatic chest Pain
- Pregnant patients or women of childbearing potential
- Patients allergic to morphine or ketamine
- Patients with known history of narcotic/alcohol abuse or presenting for narcotic
medication refill
- Patients with hypertension: diastolic blood pressure > 100 OR systolic blood pressure
> 180
- Patient whose pain is so severe that they are unable to give informed consent
- Patients who have had bad experiences to prior hallucinations from any origin
We found this trial at
1
site
Tucson, Arizona 85724
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