Protective Effects of Propranolol in Adults

A safety and efficacy trial is needed in order to determine the safety of propranolol
treatment in adult burn patients, identify which subpopulations may be most likely to benefit
from propranolol treatment and to identify propranolol dose levels that are not only safe but
potentially effective.

Inclusion Criteria:

- ≥ 20% Total Body Surface Area (TBSA) burn with anticipated operation need on admission

- Age ≥ 18 years

- Admission within 72 hours of injury

Exclusion Criteria:

- Age <18

- Patients unlikely to survive injury or with ;age = total burn size ≥ 130

- Electrical or deep chemical burn

- Malignancy currently undergoing treatment or history of cancer treatment within 5
years

- History of HIV or AIDS

- Presence of anoxic brain injury that is not expected to result in complete recovery

- Currently treated for Chronic Obstructive Pulmonary Disease (COPD), asthma or other
chronic pulmonary conditions

- History of Congestive Heart Failure (CHF) (ejection fraction < 20%)

- Pre-injury medications including blocking agents (alpha or beta) or other
anti-arrhythmic drugs

- Pregnant women

- Prisoners

- History of cardiac arrhythmia requiring medication

- Medical condition requiring glucocorticoid treatment

- Patients with concurrent conditions that in the opinion of the investigator may
compromise patient safety or study objectives