The Knee Usual Care Evaluation Study

The purpose of this prospective data collection is to track patients who are treated at HSS
who are confirmed with knee osteoarthritis. The registry will collect prospective patient
related and functional outcomes (including use of assistive devices), medication use and
imaging data on patients with confirmed osteoarthritis, and the effect of different medical
interventions that include PRP, Synvisc / Orthovisc /Euflexxa, bracing, suggested exercises,
supplements, and diet. Information from the data collection will be used to compare outcomes
of non-surgical alternatives with the end point being knee arthroplasty. The information
results will enhance our knowledge of the long-term efficacy and effectiveness of
non-surgical interventions intended to treat the progression of osteoarthritis.

Hypotheses:

- Different non-surgical interventions such as PRP, Synvisc®, Orthrovisc®, Euflexxa,
bracing, physical therapy, and a prescribed combination of exercise, diet, and
supplements will demonstrate statistically significant differences in patient pain and
functional outcomes compared to usual interventions including use of NSAIDs,
corticosteroid injections, and use of assistive devices such as canes.

- Non-operative interventions for knee osteoarthritis will be associated with different
rates of breakdown of articular cartilage and different rates of progression of
osteoarthritis as evidenced by MRI or joint space narrowing on standing knee films?

- Education about available non-operative treatment methods may change time the end point
of total or partial knee replacement for patients with knee osteoarthritis of varying
severity.

- Different non-operative interventions will be associated with different times to total
or partial knee arthroplasty in patient with knee osteoarthritis of similar severity.

- An electronic data capture system (EDC) for osteoarthritis patients will improve patient
care and patient outcomes.