A Clinical Trial for the Treatment of Depression With Repetitive Transcranial Magnetic Stimulation (rTMS)

Inclusion Criteria:

- Current major depressive disorder (MDD)

- Resistance or intolerance to antidepressant medication in the current depressive
episode, or intolerance to antidepressant medication in a past depressive episode

- On a stable psychotropic regimen prior to screening and be willing to maintain the
current regimen and dosing for the duration of the study

- Weight less than 350 pounds

Exclusion Criteria:

- Current major depressive disorder episode of more than three years

- Seizure disorder

- History of brain injury, stroke or active central nervous system disease

- Cardiac pacemaker, implanted device (deep brain stimulation) or metal in the brain,
cervical spinal cord, or upper thoracic spinal cord unless deemed MRI-safe

- Active suicidal intent or plan

- Other significant psychiatric disorder

- Alcohol or substance dependence or abuse

- Prior treatment with transcranial magnetic stimulation

- Have failed to clinically remit to an adequate trial of electroconvulsive therapy or
vagus nerve stimulation

- If female, pregnant or lactating or planning to become pregnant within the next three
months