PET Imaging of Cancer Patients Using [18F]-SKI-249380, a Radiolabeled Dasatinib-Derivative

Inclusion Criteria:

- Patients with history of histologically-confirmed neoplasm of any of the following
classifications: solid malignancy, myeloid neoplasm, lymphoid neoplasm.

- Histology confirmed by MSKCC Department of Pathology.

- Disease that is either:

- Radiologically-measurable or evaluable as defined by tumor response criteria from
an MSKCC-IRB approved clinic research protocol.

- Detectable by biopsy (eg, bone marrow) and/or peripheral blood assays obtained
within 6 weeks of study enrollment

- Age between 21-90

- Negative serum pregnancy test for females of child-bearing age (11-55 years) and
potential (ie, women who were not postmenopausal before the start of ongoing
treatment, if applicable; and who have not had a surgical intervention whose intent or
effect is sterilization, such as tubal ligation or hysterectomy.)

- Not breast-feeding, if applicable.

Exclusion Criteria:

- Refusal or inability to discontinue medications or other substances (eg, foods or
dietary supplements) that may affect [18F]-SKI-249380 metabolism. Notably, as
dasatinib metabolism is CYP3A4-dependent, the metabolism of [18F]-SKI-249380 may be
altered by inhibitors and inducers of cytochrome P450 isoenzyme CYP3A4. The
acceptability of medications and other substances used by the patient will be
determined by the study investigators.

- Inability or refusal to have at least one peripheral intravenous line for intravenous
access (as applicable to the day of [18F]-SKI-249380 injection and blood draws.)

- Refusal or inability to tolerate the scanning procedure (e.g., due to claustrophobia)

- Hepatic: from assays obtained <2 weeks prior to study enrollment

- Bilirubin > 1.5 x institutional upper limit of normal (ULN)

- AST/ALT >2.5 x ULN

- Albumin < 2 g/dl

- GGT > 2.5 x ULN IF Alkaline phosphatase > 2.5 x ULN.

- Renal: Creatinine >1.5 x ULN or creatinine clearance < 60 mL/min, from assays obtained
<2 weeks prior to study enrollment

- Acute major illness (e.g., unstable cardiovascular condition, etc.)