Measurements of Breast Tissue Optical Properties
| Status: | Withdrawn |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 2/1/2018 |
| Start Date: | December 1995 |
| End Date: | July 2018 |
Approximately twelve percent of the women in the United States will develop breast cancer,
the most common form of cancer affecting women, with 183,000 new cases projected for 1995.
Despite the increasing incidence, the age-adjusted death rate from carcinoma has remained
relatively stable. Although the reason for this has not yet been demonstrated, this stability
may be a direct consequence of early detection and improved therapy. Screening mammography as
an early detection technique has been shown to reduce mortality by 23%. Mammographic
abnormalities that go on to biopsy show 24% being positive for malignancy with great
variability (6-75%). Breast biopsy is an expensive procedure with the risks of anesthesia and
surgery which may be obviated by more specific non-invasive testing.
the most common form of cancer affecting women, with 183,000 new cases projected for 1995.
Despite the increasing incidence, the age-adjusted death rate from carcinoma has remained
relatively stable. Although the reason for this has not yet been demonstrated, this stability
may be a direct consequence of early detection and improved therapy. Screening mammography as
an early detection technique has been shown to reduce mortality by 23%. Mammographic
abnormalities that go on to biopsy show 24% being positive for malignancy with great
variability (6-75%). Breast biopsy is an expensive procedure with the risks of anesthesia and
surgery which may be obviated by more specific non-invasive testing.
Diffuse Optical Spectroscopic Imaging a new method for quantitative characterization of the
optical properties of tissues. The diagnostic tools utilize anomalies in the transmission of
diffusing near infra-red light for the rapid detection of oxygenated and deoxygenated
hemoglobin, near infra-red absorbing drug levels, blood volume changes, and scattering
properties in tissues.
Diffuse Optical Spectroscopic Imaging measurements of breast tissue optical properties probe
is similar in shape to an ultrasound probe. The imaging can measurements on different areas
of the breast including diseased location and normal area. Optical measurements can guided by
co-registered ultrasound measurements for the purpose of determining lesion size and
location. Each measurement will require about 5-60 seconds to record the data and calculate
optical properties. The process will be repeated until an adequate number of measurements are
performed and measurements take 30 to 90 minutes.
The researcher can determine that breast optical properties on demographic information, such
as age and menopausal status as well as medical history.
optical properties of tissues. The diagnostic tools utilize anomalies in the transmission of
diffusing near infra-red light for the rapid detection of oxygenated and deoxygenated
hemoglobin, near infra-red absorbing drug levels, blood volume changes, and scattering
properties in tissues.
Diffuse Optical Spectroscopic Imaging measurements of breast tissue optical properties probe
is similar in shape to an ultrasound probe. The imaging can measurements on different areas
of the breast including diseased location and normal area. Optical measurements can guided by
co-registered ultrasound measurements for the purpose of determining lesion size and
location. Each measurement will require about 5-60 seconds to record the data and calculate
optical properties. The process will be repeated until an adequate number of measurements are
performed and measurements take 30 to 90 minutes.
The researcher can determine that breast optical properties on demographic information, such
as age and menopausal status as well as medical history.
Inclusion Criteria:
- Non-pregnant woman age 18 yrs and older.
Exclusion Criteria:
- pregnant woman and younger than 18 yrs of age.
We found this trial at
4
sites
Irvine, California 92612
Principal Investigator: Bruce J Tromberg, PhD
Phone: 949-824-9265
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