Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable CAD in Post MI Patients

TIGRIS is a multinational, multi-centre, observational, prospective, longitudinal cohort
study which will include stable CAD patients with history of MI 1-3 years ago and high risk
of developing atherothrombotic events in a real world setting. The follow-up period is 3
years.

Patients will undergo clinical assessments and receive standard medical care as determined by
the treating physician. Patients will not receive experimental intervention or experimental
treatment as a consequence of their participation in the study.

Inclusion Criteria:

- Stable CAD patients aged 50 years or older with documented history of presumed
spontaneous MI with their most recent MI occurring 1 to 3 years prior to enrollment and
have at least 1 of the following risk factors: age ≥ 65 years; diabetes mellitus requiring
medication; documented history of a second prior presumed spontaneous MI (>1 year ago);
documented history of angiographic evidence of multivessel coronary artery disease; chronic
renal dysfunction.

Exclusion Criteria:

- Presence of serious co-morbidities in the opinion of the investigator which may limit
life expectancy (<1 year)

- Current participation in a blinded randomized clinical trial.

- Presence of any condition/circumstance which in the opinion of the investigator could
significantly limit the complete follow up of the patient

- Patients receiving treatment of ticagrelor beyond 12 months, or off label use of
ticagrelor.